Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice

Andrew C. Hunt, James Brett Case, Young‐Jun Park, +44

Science Translational Medicine

New VariantsViral DiagnosticsViral PathogenesisImmunologyMolecular Biology +15

Design of multi-scale protein complexes by hierarchical building block fusion

Yang Hsia, Rubul Mout, William Sheffler, +17

Nature Communications

Supramolecular AssemblyProtein AssemblyMolecular Self-assemblyMolecular BiologyOligomeric Building Blocks +16

Reconfigurable asymmetric protein assemblies through implicit negative design

Danny D. Sahtoe, Florian Praetorius, Alexis Courbet, +10

Science

De novo design of modular protein hydrogels with programmable intra- and extracellular viscoelasticity

Rubul Mout, Ross C. Bretherton, Justin Decarreau, +11

Proceedings of the National Academy of Sciences

Tissue EngineeringEngineeringBiomaterials DesignBiofabricationMacroscopic Viscoelasticity +19

Accurate computational design of three-dimensional protein crystals

Zhe Li, Shunzhi Wang, Una Nattermann, +28

Nature Materials

Crystal StructureEngineeringMolecular BiologyStructural BiologyProtein Modeling +5

Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies

Natasha I. Edman, Ashish Phal, Rachel L. Redler, +37

Cell

Tissue EngineeringFgf PathwayDevelopmental BiologyAngiogenesisEngineering +13

Sex-related outcomes after fenestrated-branched endovascular aneurysm repair for thoracoabdominal aortic aneurysms in the U.S. Fenestrated and Branched Aortic Research Consortium

Natasha I. Edman, Andres Schanzer, Allison Crawford, +10

Journal of Vascular Surgery

MedicineGynecologyVascular SurgeryU.s. FenestratedThoracoabdominal Aortic Aneurysms +1

Genetic Analysis of the CDI Pathway from Burkholderia pseudomallei 1026b

Sanna Koskiniemi, Fernando Garza‐Sánchez, Natasha I. Edman, +5

PLoS ONE

Women with thoracoabdominal aortic aneurysms have increased frailty and more complex aortic anatomy compared with men

Natasha I. Edman, Sara L. Zettervall, Maianna N. Dematteis, +3

Journal of Vascular Surgery

Cardiovascular DiseaseAortic DiseasesMedicineArterial DiseasePublic Health +4

Multivalent designed proteins protect against SARS-CoV-2 variants of concern

Andrew C. Hunt, James Brett Case, Young‐Jun Park, +43