Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor β Signaling

Susann Weissmueller, Eusebio Manchado, Michael Saborowski, +15

Cell

Tumor BiologyPancreatic CancerMedicineCancer Cell BiologyTumor Suppressor +5

A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia

Sohela Shah, Kasmintan A. Schrader, Esmé Waanders, +67

Nature Genetics

Hematological MalignancyLymphoid NeoplasiaMixed-phenotype Acute LeukemiaGeneticsHematology +5

MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia

Chong Chen, Yu Liu, Amy Rappaport, +13

Cancer Cell

Hematological MalignancyMedicineAcute Myeloid LeukemiaHematologyMyeloid Neoplasia +8

Integrin Trafficking Regulated by Rab21 Is Necessary for Cytokinesis

Teijo Pellinen, Antti Arjonen, Maija Wolf, +9

Developmental Cell

Signal TransductionIntegrin TraffickingCell TraffickingEndocytic PathwayIntracellular Trafficking +5

CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma

Chun‐Hao Huang, Amaia Lujambio, Johannes Zuber, +11

Genes & Development

Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion

Thomas Kitzing, Arul S. Sahadevan, Dominique T. Brandt, +5

Genes & Development

Positive FeedbackMolecular RegulationRhoa-effector Dia1Molecular BiologyCytoskeleton +19

A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions

Wen Xue, Thomas Kitzing, Stéphanie Roessler, +15

Proceedings of the National Academy of Sciences

GeneticsMolecular GeneticsEpigeneticsTumor BiologyCancer Genomes +16

Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC

Thomas Kitzing, Ying Wang, Olivier Pertz, +2

Oncogene

Signal TransductionMedicineNatural SciencesMolecular BiologyCell Migration +8

SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of β1-integrin

Dominique T. Brandt, Christian Baarlink, Thomas Kitzing, +4

Nature Cell Biology

Transcriptional RegulationSignal TransductionSignaling PathwayCell RegulationMedicine +11

Gα12/13 Is Essential for Directed Cell Migration and Localized Rho-Dia1 Function

Polyxeni Goulimari, Thomas Kitzing, Helga Knieling, +3

Journal of Biological Chemistry