Innate Immune Sensing of Modified Vaccinia Virus Ankara (MVA) Is Mediated by TLR2-TLR6, MDA-5 and the NALP3 Inflammasome

Julie Delaloye, Thierry Roger, Quynh-Giao Steiner-Tardivel, +10

PLoS Pathogens

Nalp3 InflammasomeInnate Immune SystemImmunologyImmune RegulationImmunologic Mechanism +15

Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates

Barbara J. Flynn, Kathrin Kastenmüller, Ulrike Wille-Reece, +14

Proceedings of the National Academy of Sciences

Movements of vaccinia virus intracellular enveloped virions with GFP tagged to the F13L envelope protein

Maria Moreno Geada, Inmaculada Galindo, Marı́a M. Lorenzo, +2

Journal of General Virology

Cryo X-ray nano-tomography of vaccinia virus infected cells

Francisco Javier Chichón, María Josefa Rodríguez, Eva Pereiro, +8

Journal of Structural Biology

EngineeringElectron MicroscopyMicroscopyBiomedical ImagingCryo X-ray Nano-tomography +5

Safety and immunogenicity of a modified pox vector-based HIV/AIDS vaccine candidate expressing Env, Gag, Pol and Nef proteins of HIV-1 subtype B (MVA-B) in healthy HIV-1-uninfected volunteers: A phase I clinical trial (RISVAC02)

Felipe García, Juan Carlos López Bernaldo de Quirós, Carmen Gómez, +22

Vaccine

VaccinationVaccine DevelopmentHealthy Hiv-1-uninfected VolunteersNef ProteinsMedicine +8

The HIV/AIDS Vaccine Candidate MVA-B Administered as a Single Immunogen in Humans Triggers Robust, Polyfunctional, and Selective Effector Memory T Cell Responses to HIV-1 Antigens

Carmen Gómez, José Luis Nájera, Beatriz Perdiguero, +11

Journal of Virology

T Cell ResponsesAdaptive Immune SystemImmunodeficienciesImmunologyImmunodominance +19

Improved NYVAC-Based Vaccine Vectors

Karen V. Kibler, Carmen Gómez, Beatriz Perdiguero, +14

PLoS ONE

Viral ReplicationNyvac-based Vaccine VectorsPrime/boost Vaccine CombinationImmunologyImmunodominance +19

Safety and immunogenicity of a modified vaccinia Ankara-based HIV-1 vaccine (MVA-B) in HIV-1-infected patients alone or in combination with a drug to reactivate latent HIV-1

Beatriz Mothe, Núria Climent, Montserrat Plana, +26

Journal of Antimicrobial Chemotherapy

Improving the MVA Vaccine Potential by Deleting the Viral Gene Coding for the IL-18 Binding Protein

Juliana Falivene, María Paula Del Médico Zajac, María Fernanda Pascutti, +7

PLoS ONE

Improved Innate and Adaptive Immunostimulation by Genetically Modified HIV-1 Protein Expressing NYVAC Vectors

Esther D. Quakkelaar, Anke Redeker, Elias K. Haddad, +20

PLoS ONE

ImmunologyViral PathogenesisCd4 T Cell ResponsesInnate ImmunityImmunotherapy +14