NASH limits anti-tumour surveillance in immunotherapy-treated HCC

Dominik Pfister, Nicolás Gonzalo Núñez, Roser Pinyol, +107

Nature

Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH

Michael Dudek, Dominik Pfister, Sainitin Donakonda, +45

Nature

Autoimmune DiseaseHepatologyImmune PathologyLiver PhysiologyT-regulatory Cell +10

Cardiac glycosides are broad-spectrum senolytics

Ana Guerrero, Nicolás Herranz, Bin Sun, +23

Nature Metabolism

Cardiac MuscleCardiomyopathyGlycosylationBiochemistryMedicine +3

HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice

Rouven Hoefflin, Sabine Harlander, Silvia Schäfer, +22

Nature Communications

PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells

Athena Georgilis, Sabrina Klotz, Christopher J. Hanley, +19

Cancer Cell

Inhibition of LTβR signalling activates WNT-induced regeneration in lung

Thomas M. Conlon, Gerrit John-Schuster, Danijela Heide, +45

Nature

Activates Wnt-induced RegenerationLung InflammationMedicineCell BiologyCell Signaling +1

Hepatitis B virus-induced modulation of liver macrophage function promotes hepatocyte infection

Suzanne Faure‐Dupuy, Marion Delphin, Ludovic Aillot, +16

Journal of Hepatology

InflammationHepatologyHepatocyte InfectionViral HepatitisLiver Physiology +10

Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis

Mahak Singhal, Nicolas Gengenbacher, Ashik Ahmed Abdul Pari, +21

Science Translational Medicine

A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1

Suchira Gallage, Adnan Ali, Jose Efren Barragan Avila, +31

Cell Metabolism

Hepatic PparαImmunologyPathologyFatty Liver DiseaseCirrhosis +25

Combined hepatocellular-cholangiocarcinoma derives from liver progenitor cells and depends on senescence and IL-6 trans-signaling

Nofar Rosenberg, Matthias Van Haele, Tali Lanton, +34

Journal of Hepatology

Liver Progenitor CellsHepatologyHepatocellular CarcinomaBiliary CancerLiver Physiology +13