Ann Hedley

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

Christian Frezza, Liang Zheng, Ori Folger et al. · Nature · 2011 · 535 citations

Life Sciences, Biochemistry, Cancer Biology +12

Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis

René Jackstadt, Sander R. van Hooff, Joshua D.G. Leach et al. · Cancer Cell · 2019 · 449 citations · Full text

Medicine, Cancer Biology, Oncology +17

The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer

Arafath K. Najumudeen, Fatih Ceteci, Sigrid K. Fey et al. · Nature Genetics · 2021 · 329 citations · Full text

Medicine, Molecular Biology, Oncology +12

Fumarate induces redox-dependent senescence by modifying glutathione metabolism

Liang Zheng, Simone Cardaci, Livnat Jerby et al. · Nature Communications · 2015 · 292 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence

Thomas G. Bird, Miryam Müller, Luke Boulter et al. · Science Translational Medicine · 2018 · 264 citations · Full text

Life Sciences, Cell Biology, Cell Signaling +14