Inhibition of the TGF-β receptor I kinase promotes hematopoiesis in MDS

Li Zhou, Aaron Nguyen, Davendra Sohal, +23

Blood

High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers

Mayumi Oda, Jacob L. Glass, Reid F. Thompson, +14

Nucleic Acids Research

Epigenetic ChangeGeneticsMspi RepresentationMolecular BiologyLimited Cell Numbers +17

Widespread Hypomethylation Occurs Early and Synergizes with Gene Amplification during Esophageal Carcinogenesis

Héctor M. Álvarez, Joanna Opalinska, Li Zhou, +21

PLoS Genetics

Gene AmplificationEsophageal CancerEpigenetic ChangeGeneticsPathology +16

Reduced SMAD7 Leads to Overactivation of TGF-β Signaling in MDS that Can Be Reversed by a Specific Inhibitor of TGF-β Receptor I Kinase

Li Zhou, Christine M. McMahon, Tushar D. Bhagat, +24

Cancer Research

Smad7 LeadsTgf-β ReceptorImmunologyImmune RegulationPathology +21

Methylome Profiling Reveals Distinct Alterations in Phenotypic and Mutational Subgroups of Myeloproliferative Neoplasms

Sangeeta Nischal, Sanchari Bhattacharyya, Maximilian Christopeit, +15

Cancer Research

EngineeringEpigenetic ChangeGeneticsDna MethylationMyeloproliferative Neoplasms +17

Aberrant Epigenetic and Genetic Marks Are Seen in Myelodysplastic Leukocytes and Reveal Dock4 as a Candidate Pathogenic Gene on Chromosome 7q

Li Zhou, Joanna Opalinska, Davendra Sohal, +27

Journal of Biological Chemistry

CytogeneticsSignificant HypermethylationGeneticsMds LeukocytesEpigenetic Change +17

High Resolution Methylome Analysis Reveals Widespread Functional Hypomethylation during Adult Human Erythropoiesis

Yiting Yu, Yongkai Mo, David L. Ebenezer, +19

Journal of Biological Chemistry

The RUNX1/IL-34/CSF-1R axis is an autocrinally regulated modulator of resistance to BRAF-V600E inhibition in melanoma

Orsi Giricz, Yongkai Mo, Kimberly B. Dahlman, +25

JCI Insight

ImmunologyImmunotherapyCancer BiologyTumor BiologyRegulated Modulator +14

Inhibition of p38α MAPK disrupts the pathological loop of proinflammatory factor production in the myelodysplastic syndrome bone marrow microenvironment

Tony Navas, Li Zhou, Myka L. Estes, +10

Leukemia & lymphoma/Leukemia and lymphoma

Meta-Analysis of Microarray Studies Reveals a Novel Hematopoietic Progenitor Cell Signature and Demonstrates Feasibility of Inter-Platform Data Integration

Davendra Sohal, Andrew B. Yeatts, Kenny Ye, +10

PLoS ONE

Global Gene ExpressionEngineeringMixed-phenotype Acute LeukemiaTranscriptomics TechnologyGene Expression Profiling +16