Chunpu Li

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

Wenhao Dai, Bing Zhang, Xia-Ming Jiang et al. · Science · 2020 · 1.6K citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Tanshinone IIA inhibits β-catenin/VEGF-mediated angiogenesis by targeting TGF-β1 in normoxic and HIF-1α in hypoxic microenvironments in human colorectal cancer

Hua Sui, Jihui Zhao, Lihong Zhou et al. · Cancer Letters · 2017 · 160 citations

Medicine, Cancer Biology, Oncology +16

Deep Learning Enhancing Kinome-Wide Polypharmacology Profiling: Model Construction and Experiment Validation

Xutong Li, Zhaojun Li, Xiaolong Wu et al. · Journal of Medicinal Chemistry · 2019 · 104 citations

Pharmacy, Bioinformatics, Pharmacology +16

Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies

Xuewu Liang, Jie Zang, Xiaoyang Li et al. · Journal of Medicinal Chemistry · 2019 · 85 citations · Full text

Medicine, Oncology, Pharmacology +16

Inhibition of β-catenin/B cell lymphoma 9 protein−protein interaction using α-helix–mimicking sulfono-γ-AApeptide inhibitors

Peng Sang, Min Zhang, Yan Shi et al. · Proceedings of the National Academy of Sciences · 2019 · 80 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15