Melvin Churchill

Processing of tumour necrosis factor-α precursor by metalloproteinases

A. J. H. Gearing, Paul Beckett, Marika Christodoulou et al. · Nature · 1994 · 1.2K citations

Life Sciences, Biochemistry, Pathology +11

Ixekizumab for the treatment of patients with active psoriatic arthritis and an inadequate response to tumour necrosis factor inhibitors: results from the 24-week randomised, double-blind, placebo-controlled period of the SPIRIT-P2 phase 3 trial

Peter Nash, Bruce Kirkham, Masato Okada et al. · The Lancet · 2017 · 405 citations · Full text

Medicine, Immunology, Pharmacotherapy +13

Golimumab, a human anti–tumor necrosis factor α monoclonal antibody, injected subcutaneously every four weeks in methotrexate‐naive patients with active rheumatoid arthritis: Twenty‐four–week results of a phase III, multicenter, randomized, double‐blind, placebo‐controlled study of golimumab before methotrexate as first‐line therapy for early‐onset rheumatoid arthritis

Paul Emery, Roy Fleischmann, Larry W. Moreland et al. · Arthritis & Rheumatism · 2009 · 396 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +14

Ixekizumab, an interleukin-17A antagonist in the treatment of ankylosing spondylitis or radiographic axial spondyloarthritis in patients previously untreated with biological disease-modifying anti-rheumatic drugs (COAST-V): 16 week results of a phase 3 randomised, double-blind, active-controlled and placebo-controlled trial

Désirée van der Heijde, James Cheng‐Chung Wei, Maxime Dougados et al. · The Lancet · 2018 · 359 citations · Full text

Medicine, Internal Medicine, Pharmacotherapy +14

Treatment of rheumatoid arthritis with methotrexate and hydroxychloroquine, methotrexate and sulfasalazine, or a combination of the three medications: Results of a two‐year, randomized, double‐blind, placebo‐controlled trial

James R. O’Dell, Robert D. Leff, Gail Paulsen et al. · Arthritis & Rheumatism · 2002 · 322 citations

Medicine, Clinical Sciences, Pharmacology +10