Spiros Liras

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

Tina R. White, Chad M. Renzelman, Arthur C Rand et al. · Nature Chemical Biology · 2011 · 373 citations

Medicinal Chemistry, Biochemistry, Natural Sciences +7

Enantioselective Intramolecular Cyclopropanations of Allylic and Homoallylic Diazoacetates and Diazoacetamides Using Chiral Dirhodium(II) Carboxamide Catalysts

Michael P. Doyle, Richard E. Austin, A. S. Bailey et al. · Journal of the American Chemical Society · 1995 · 215 citations

Enantioselective Synthesis, Engineering, Donut Icon +12

Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1 <i>H</i> -pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia†Coordinates of the PDE10A crystal structures have been deposited in the Protein Data Bank for compound 1 (3HQW), 2 (3HQY), 3 (3HQW) and 9 (3HR1).

Patrick R. Verhoest, Douglas S. Chapin, Michael L. Corman et al. · Journal of Medicinal Chemistry · 2009 · 201 citations · Full text

Comparative α‐Helicity of Cyclic Pentapeptides in Water

Aline D. de Araujo, Huy N. Hoang, W. Mei Kok et al. · Angewandte Chemie International Edition · 2014 · 174 citations

Protein Chemistry, Helix Induction, Biochemistry +13

Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients

Conan K. Wang, Susan E. Northfield, Barbara Colless et al. · Proceedings of the National Academy of Sciences · 2014 · 165 citations · Full text