Jose Roques

Targeted inhibition of gut bacterial β-glucuronidase activity enhances anticancer drug efficacy

Aadra P. Bhatt, Samuel J. Pellock, Kristen A. Biernat et al. · Proceedings of the National Academy of Sciences · 2020 · 204 citations · Full text

Medicine, Oncology, Pharmacology +16

New Mechanisms of Resistance to MEK Inhibitors in Melanoma Revealed by Intravital Imaging

Hailey E. Brighton, Steven P. Angus, Tao Bo et al. · Cancer Research · 2017 · 70 citations · Full text

Medicine, Oncology, Pharmacology +17

Competitive Kinase Enrichment Proteomics Reveals that Abemaciclib Inhibits GSK3β and Activates WNT Signaling

Emily Cousins, Dennis Goldfarb, Feng Yan et al. · Molecular Cancer Research · 2017 · 56 citations · Full text

Life Sciences, Biochemistry, Pharmacology +15

A Fluorescent Hsp90 Probe Demonstrates the Unique Association between Extracellular Hsp90 and Malignancy <i>in Vivo</i>

Lauren B. Crowe, Philip F. Hughes, David A. Alcorta et al. · ACS Chemical Biology · 2017 · 55 citations

Medicine, Molecular Biology, Oncology +17

Identification of harmine and β-carboline analogs from a high-throughput screen of an approved drug collection; profiling as differential inhibitors of DYRK1A and monoamine oxidase A and for in vitro and in vivo anti-cancer studies

Michael Tarpley, Helen Oladapo, Dillon Strepay et al. · European Journal of Pharmaceutical Sciences · 2021 · 44 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10