Sudarshan Kapadnis

Prospective Validation of Machine Learning Algorithms for Absorption, Distribution, Metabolism, and Excretion Prediction: An Industrial Perspective

Cheng Fang, Ye Wang, Richard Grater et al. · Journal of Chemical Information and Modeling · 2023 · 76 citations

Pharmacy, Pharmacokinetics, Pharmacology +14

Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis

Brian T. Hopkins, Eris Bame, Bekim Bajrami et al. · Journal of Medicinal Chemistry · 2021 · 42 citations · Full text

Pharmacy, Medicinal Chemistry, Neurology +14

Design, Synthesis, and Evaluation of a Novel Series of Oxadiazine Gamma Secretase Modulators for Familial Alzheimer’s Disease

Matthew G. Bursavich, Bryce A. Harrison, Raksha Acharya et al. · Journal of Medicinal Chemistry · 2017 · 29 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer’s disease

Jean‐François Blain, Matthew G. Bursavich, Emily A. Freeman et al. · Alzheimer s Research & Therapy · 2016 · 20 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Optimization of dose and route of administration of the P‐glycoprotein inhibitor, valspodar (PSC‐833) and the P‐glycoprotein and breast cancer resistance protein dual‐inhibitor, elacridar (GF120918) as dual infusion in rats

Christopher Rowbottom, Alicia Pietrasiewicz, Taras Tuczewycz et al. · Pharmacology Research & Perspectives · 2021 · 16 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +15