Lindsey Crowley

MEK inhibition leads to BRCA2 downregulation and sensitization to DNA damaging agents in pancreas and ovarian cancer models

Francesca Vena, Ruochen Jia, Arman Esfandiari et al. · Oncotarget · 2018 · 48 citations · Full text

Brain penetration and efficacy of tepotinib in orthotopic patient-derived xenograft models of MET-driven non-small cell lung cancer brain metastases

Manja Friese‐Hamim, Anderson Clark, Dominique Perrin et al. · Lung Cancer · 2021 · 25 citations

Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology

Timo Heinrich, Ada Sala-Hojman, Roberta Ferretti et al. · Journal of Medicinal Chemistry · 2021 · 19 citations · Full text

Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers

Lizbeth DeSelm, Bayard R. Huck, Ruoxi Lan et al. · Journal of Medicinal Chemistry · 2021 · 11 citations · Full text