Adrian M. Isaacs

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

Mike Hutton, Corinne Lendon, Patrizia Rizzu et al. · Nature · 1998 · 3.5K citations

Neurodegenerative Diseases, Mendelian Disorder, Genetic Disorder +8

<i>C9orf72</i> repeat expansions cause neurodegeneration in <i>Drosophila</i> through arginine-rich proteins

Sarah Mizielinska, Sebastian Grönke, Teresa Niccoli et al. · Science · 2014 · 735 citations · Full text

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse

Patrick M. Nolan, Jo Peters, Mark Strivens et al. · Nature Genetics · 2000 · 655 citations

Knockout Mouse, Transgenic Mouse Models, Genetics +11

Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease

Maria Filimonenko, Susanne Stuffers, Camilla Raiborg et al. · The Journal of Cell Biology · 2007 · 623 citations · Full text

Mitophagy, Protein Aggregates, Functional Multivesicular Bodies +19

The heritability and genetics of frontotemporal lobar degeneration

Jonathan D. Rohrer, Rita Guerreiro, Jana Vandrovcová et al. · Neurology · 2009 · 518 citations · Full text