Peptide-mediated delivery of CRISPR enzymes for the efficient editing of primary human lymphocytes

Dana V. Foss, Joseph J. Muldoon, David N. Nguyen, +14

Nature Biomedical Engineering

Efficient EditingEngineeringGenome SurgeryImmunologySynthetic Biology +10

An evolved AAV variant enables efficient genetic engineering of murine T cells

William A. Nyberg, Jonathan Ark, Angela To, +15

Cell

Base-editing mutagenesis maps alleles to tune human T cell functions

Ralf Schmidt, Carl C. Ward, Rama Dajani, +17

Nature

GeneticsGenetic EngineeringGenetic MechanismMolecular GeneticsGene Editing +4

Clinical and Molecular Determinants of Clonal Evolution in Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Carmelo Gurnari, Simona Pagliuca, Pedro Henrique Prata, +20

Journal of Clinical Oncology

Effect of early granulocyte-colony-stimulating factor administration in the prevention of febrile neutropenia and impact on toxicity and efficacy of anti-CD19 CAR-T in patients with relapsed/refractory B-cell lymphoma

Raphaël Liévin, Roberta Di Blasi, Florence Morin, +12

Bone Marrow Transplantation

PROMIDISα: A T-cell receptor α signature associated with immunodeficiencies caused by V(D)J recombination defects

Aurélie Berland, Jérémie Rosain, Sophie Kaltenbach, +26

Journal of Allergy and Clinical Immunology

Immune Cell DevelopmentImmunodeficienciesT-regulatory CellImmunologyJ Recombination Defects +5

G-CSF does not worsen toxicities and efficacy of CAR-T cells in refractory/relapsed B-cell lymphoma

Eugenio Galli, Vincent Allain, Roberta Di Blasi, +7

Bone Marrow Transplantation

Lymphoid NeoplasiaMedicineImmunologyRefractory/relapsed B-cell LymphomaImmunotherapy +4

A major role for CD4+ T cells in driving cytokine release syndrome during CAR T cell therapy

Morgane Boulch, Marine Cazaux, Alexis Cuffel, +10

Cell Reports Medicine

Droplet digital PCR allows vector copy number assessment and monitoring of experimental CAR T cells in murine xenograft models or approved CD19 CAR T cell-treated patients

Rafik Haderbache, Walid Warda, Éric Hervouet, +21

Journal of Translational Medicine

Real-world characteristics of T-cell apheresis and clinical response to tisagenlecleucel in B-cell lymphoma

Alexis Cuffel, Vincent Allain, Lionel Faivre, +13

Blood Advances