Joseph F. Kleha

Constitutive endothelin-1 overexpression promotes smooth muscle cell proliferation via an external autocrine loop

Gregory F. Alberts, Kimberly A. Peifley, A. Johns et al. · Journal of Biological Chemistry · 1994 · 139 citations · Full text

Life Sciences, Cell Biology, Physiology +13

First-in-Human Phase I Study of GSK2126458, an Oral Pan-Class I Phosphatidylinositol-3-Kinase Inhibitor, in Patients with Advanced Solid Tumor Malignancies

Pamela N. Münster, Rahul Aggarwal, David S. Hong et al. · Clinical Cancer Research · 2015 · 112 citations · Full text

Medicine, Oncology, Pharmacology +15

Phase I dose-escalation trial of the oral AKT inhibitor uprosertib in combination with the oral MEK1/MEK2 inhibitor trametinib in patients with solid tumors

Anthony W. Tolcher, Razelle Kurzrock, V. Valero et al. · Cancer Chemotherapy and Pharmacology · 2020 · 58 citations · Full text

Medicine, Oncology, Pharmacology +15

A randomized, double-blind, placebo-controlled study to evaluate the effect of repeated oral doses of pazopanib on cardiac conduction in patients with solid tumors

Elisabeth I. Heath, Jeffrey R. Infante, Lionel D. Lewis et al. · Cancer Chemotherapy and Pharmacology · 2013 · 42 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +7

Phase I first-in-human study of the PI3 kinase inhibitor GSK2126458 (GSK458) in patients with advanced solid tumors (study P3K112826).

Pamela N. Münster, Ruud van der Noll, Emile E. Voest et al. · Journal of Clinical Oncology · 2011 · 27 citations

Medicine, Oncology, Pharmacology +13