IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants.

Gianfranco Del Prete, Enrico Maggi, Paola Parronchi, +7

The Journal of Immunology

Lymphocyte DevelopmentT-regulatory CellImmunologyImmune RegulationImmunologic Mechanism +16

Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production.

G. Prete, Marco Carli, C. Mastromauro, +5

Journal of Clinical Investigation

Laboratory ImmunologyImmune RegulationImmunologyAntigen ProcessingCd4 T Cell Responses +15

Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones

Enrico Maggi, Paola Parronchi, Roberto Manetti, +6

The Journal of Immunology

Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production.

Paola Parronchi, Donatella Macchia, Marie‐Pierre Piccinni, +6

Proceedings of the National Academy of Sciences

AsthmaEnvironmental AllergyAdaptive Immune SystemEighteen TccsImmunology +19

Accumulation of Th-2-like helper T cells in the conjunctiva of patients with vernal conjunctivitis

Enrico Maggi, Priscilla Biswas, Gianfranco Del Prete, +7

The Journal of Immunology

Helper activity for immunoglobulin synthesis of T helper type 1 (Th1) and Th2 human T cell clones: the help of Th1 clones is limited by their cytolytic capacity.

G. Prete, Marco Carli, M Ricci, +1

The Journal of Experimental Medicine

Th2 ClonesT-regulatory CellImmunologyImmunodominanceImmunologic Mechanism +17

Cytolytic T cells with Th1-like cytokine profile predominate in retroorbital lymphocytic infiltrates of Graves' ophthalmopathy.

Marco Carli, Mario Milco D’Elios, Stefano Mariotti, +5

The Journal of Clinical Endocrinology & Metabolism

InflammationCytolytic T CellsAutoimmune DiseaseRo T CellsT-regulatory Cell +12

Defective in vitro production of gamma-interferon and tumor necrosis factor-alpha by circulating T cells from patients with the hyper-immunoglobulin E syndrome.

Gianfranco Del Prete, A Tiri, Enrico Maggi, +7

Journal of Clinical Investigation

Clinical ImmunologyHyper-ige SyndromeLaboratory ImmunologyImmunodeficienciesT-regulatory Cell +18

Surface immunoglobulins are involved in the interaction of protein A with human B cells and in the triggering of B cell proliferation induced by protein A-containing <i>Staphylococcus aureus</i>.

Sergio Romagnani, M G Giudizi, R Biagiotti, +4

The Journal of Immunology

Human bone marrow non-B, non-T cells produce interleukin 4 in response to cross-linkage of Fc epsilon and Fc gamma receptors.

Marie‐Pierre Piccinni, Donatella Macchia, Paola Parronchi, +7

Proceedings of the National Academy of Sciences

ImmunologyImmune RegulationImmunologic MechanismCd4 T Cell ResponsesImmune System +16