Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

Martin Steger, Francesca Tonelli, Genta Ito, +14

eLife

MitophagyMolecular BiologyRab GtpasesLrrk2 Kinase InhibitorsSignaling Pathway +14

Tumors induce de novo steroid biosynthesis in T cells to evade immunity

Bidesh Mahata, Jhuma Pramanik, Louise van der Weyden, +14

Nature Communications

Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation

Johan Henriksson, Xi Chen, Tomás Gomes, +8

Cell

Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors

Genta Ito, Kristina Katsemonova, Francesca Tonelli, +8

Biochemical Journal

Signal RecognitionMolecular BiologyPhos-tag AnalysisMajor Rab10 KinaseCell Regulation +17

BACE1 (β-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes

Steve Harrison, Alex Harper, Julie A. Hawkins, +11

Molecular and Cellular Neuroscience

Behavioral ChangesMolecular NeuroscienceBehavioral NeuroscienceNeurotransmitterNeurochemical Deficits +10

Molecular and pharmacological characterization of genes encoding urotensin‐II peptides and their cognate G‐protein‐coupled receptors from the mouse and monkey

Nabil A. Elshourbagy, Stephen A. Douglas, Usman Shabon, +8

British Journal of Pharmacology

Molecular PharmacologyUrologyMolecular PhysiologySignal TransductionPharmacological Characterization +13

Evaluation of expression and function of the H+/myo-inositol transporter HMIT

Elena Di Daniel, M. H. Selina Mok, Emma Mead, +9

BMC Cell Biology

Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis

Malgorzata Gozdecka, Monika Dudek, Sean Wen, +39

Nature

Genome-wide screening reveals the genetic basis of mammalian embryonic eye development

Justine M. Chee, Louise Lanoue, Dave Clary, +205

BMC Biology

Characterisation of a K390R ITK Kinase Dead Transgenic Mouse – Implications for ITK as a Therapeutic Target

Angela M. Deakin, Graham Duddy, Steve Wilson, +14

PLoS ONE