The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies

Shogo Kumagai, Yosuke Togashi, Takahiro Kamada, +28

Nature Immunology

Cancer ImmunosurveillanceAutoimmune DiseaseT-regulatory CellPd-1 Expression BalanceClinical Efficacy +10

Randomized Phase 2 Study of Osimertinib Plus Bevacizumab Versus Osimertinib for Untreated Patients With Nonsquamous NSCLC Harboring EGFR Mutations: WJOG9717L Study

Hirotsugu Kenmotsu, Kazushige Wakuda, Keita Mori, +16

Journal of Thoracic Oncology

Phase III KEYNOTE-789 Study of Pemetrexed and Platinum With or Without Pembrolizumab for Tyrosine Kinase Inhibitor‒Resistant, <i>EGFR</i> –Mutant, Metastatic Nonsquamous Non–Small Cell Lung Cancer

James Chih‐Hsin Yang, Dae Ho Lee, Jong‐Seok Lee, +208

Journal of Clinical Oncology

Non-small cell lung cancer with loss of expression of the SWI/SNF complex is associated with aggressive clinicopathological features, PD-L1-positive status, and high tumor mutation burden

Tomoyuki Naito, Hibiki Udagawa, Shigeki Umemura, +9

Lung Cancer

OncologyMedicineSwi/snf ComplexPd-l1-positive StatusAggressive Clinicopathological Features +10

Successful treatment with nivolumab for SMARCA4‐deficient non‐small cell lung carcinoma with a high tumor mutation burden: A case report

Tomoyuki Naito, Shigeki Umemura, Hiroshi Nakamura, +11

Thoracic Cancer

Association of Serum Anti-GAD Antibody and HLA Haplotypes with Type 1 Diabetes Mellitus Triggered by Nivolumab in Patients with Non–Small Cell Lung Cancer

Yuko Usui, Hibiki Udagawa, Shingo Matsumoto, +9

Journal of Thoracic Oncology

Type 1Diabetes Mellitus TriggeredAutoimmune DiseaseMedicineDiabetes +7

Feasibility and utility of transbronchial cryobiopsy in precision medicine for lung cancer: Prospective single‐arm study

Hibiki Udagawa, Keisuke Kirita, Tomoyuki Naito, +10

Cancer Science

The CLIP1–LTK fusion is an oncogenic driver in non‐small‐cell lung cancer

Hiroki Izumi, Shingo Matsumoto, Jie Liu, +35

Nature

Oncogenic AgentMedicineNon‐small‐cell Lung CancerPathologyCancer Cell Biology +8

A Phase II Study of Osimertinib for Radiotherapy-Naive Central Nervous System Metastasis From NSCLC: Results for the T790M Cohort of the OCEAN Study (LOGIK1603/WJOG9116L)

Hiroyuki Yamaguchi, Kazushige Wakuda, Minoru Fukuda, +17

Journal of Thoracic Oncology

CD200-positive cancer associated fibroblasts augment the sensitivity of Epidermal Growth Factor Receptor mutation-positive lung adenocarcinomas to EGFR Tyrosine kinase inhibitors

Masayuki Ishibashi, Shinya Neri, Hiroko Hashimoto, +14

Scientific Reports