Binding interaction of quercetin-3-β-galactoside and its synthetic derivatives with SARS-CoV 3CLpro: Structure–activity relationship studies reveal salient pharmacophore features

Lili Chen, Jian Li, Cheng Luo, +8

Bioorganic & Medicinal Chemistry

Molecular PharmacologyPharmaceutical ScienceBiochemistrySars-cov 3ClproMedicine +7

d-Alanine:d-alanine ligase as a new target for the flavonoids quercetin and apigenin

Dalei Wu, Yunhua Kong, Cong Han, +4

International Journal of Antimicrobial Agents

PhytoalexinBiosynthesisBiochemistryMedicineFlavonoids Quercetin +4

Cinanserin Is an Inhibitor of the 3C-Like Proteinase of Severe Acute Respiratory Syndrome Coronavirus and Strongly Reduces Virus Replication In Vitro

Lili Chen, Chunshan Gui, Xiaomin Luo, +17

Journal of Virology

The nucleocapsid protein of SARS coronavirus has a high binding affinity to the human cellular heterogeneous nuclear ribonucleoprotein A1

Hai‐Bin Luo, Qing Chen, Jing Chen, +3

FEBS Letters

Structural and Functional Characterization of Falcipain-2, a Hemoglobinase from the Malarial Parasite Plasmodium falciparum

Tanis Hogg, Krishna Nagarajan, Saskia Herzberg, +7

Journal of Biological Chemistry

Two adjacent mutations on the dimer interface of SARS coronavirus 3C-like protease cause different conformational changes in crystal structure

Tiancen Hu, Yu Zhang, Lianwei Li, +6

Virology

Virus StructureCrystal StructureAdjacent MutationsBiochemistryNatural Sciences +7

Severe Acute Respiratory Syndrome Coronavirus 3C-like Proteinase N Terminus Is Indispensable for Proteolytic Activity but Not for Enzyme Dimerization

Lili Chen, Jinzhi Tan, Jing Chen, +6

Journal of Biological Chemistry

Identification of an epitope of SARS-coronavirus nucleocapsid protein

Ying Lin, Xu Shen, Ruifu Yang, +16

Cell Research

Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations

Yechun Xu, Minjun Li, Harry M. Greenblatt, +10

Acta Crystallographica Section D Biological Crystallography

Membrane StructureBiophysical ModelingProtein AssemblyClosed ConformationMolecular Biology +24

Residues on the Dimer Interface of SARS Coronavirus 3C-like Protease: Dimer Stability Characterization and Enzyme Catalytic Activity Analysis

Shuai Chen, Jian Zhang, Tao Hu, +3

The Journal of Biochemistry

Virus StructureViral ReplicationProtein AssemblyBiochemistryProtein Folding +11