21:I[432972,["/_next/static/chunks/bb923814e1f4d2e9.js","/_next/static/chunks/dd3ee9f5b7716ca6.js","/_next/static/chunks/4204a0ae82542ca8.js","/_next/static/chunks/30036bedc5269936.js","/_next/static/chunks/6e1aa89a642f40be.js","/_next/static/chunks/cd5e572bc3e4eb92.js","/_next/static/chunks/8ffd0b71567920d8.js","/_next/static/chunks/959ed6555b8dc5ff.js","/_next/static/chunks/24eb4379f68013fd.js","/_next/static/chunks/b8cd775ffdf935bd.js","/_next/static/chunks/983103cd9eb7b428.js","/_next/static/chunks/d4ac9dcf27f6ff52.js","/_next/static/chunks/294b9525248c8e5f.js"],"default"] 22:T48a,Growth factors play a vital role in wound healing, and novel hydrogel carriers suitable for growth factors have always been a research hotspot in the wound healthcare field. In this work, a wound microenvironment-responsive hydrogel drug-loading system was constructed by cross-linking of the internal electron-deficient polyester and bovine serum albumin (BSA) via catalyst-free amino-yne bioconjugation. The slightly acidic microenvironment of wound tissues induces the charge removal of BSA chains, thus releasing the basic fibroblast growth factor (bFGF) loaded through electrostatic action. Besides, the BSA chains in the gel network further endow their excellent biocompatibility and biodegradability, also making them more suitable for bFGF loading. The wound caring evaluation of the hydrogel in the full-thickness skin wound indicated that the protein-based hydrogel significantly promotes the proliferation and differentiation of fibroblasts, collagen accumulation, and epidermal layer stacking, thus significantly shortening the healing process. This strategy paved the way for broadening the application of the growth factors in the wound care field.23:T49a,Infections caused by pathogenic microorganisms have always been the Achilles heel in the clinic. In this work, to overcome this conundrum, we proposed an injectable multifunctional hydrogel material with outstanding antibacterial properties and self-healing properties and no adverse effects on health. The cross-linked hydrogel with three-dimensional (3D) networks was quickly formed via the dynamic Schiff base between amino-modified poly-tetrahydropyrimidine (PTHP-NH₂) and multiple vanillin polymer P(DMA-VA) in 30 s. This hydrogel composite presents effective defense against both Gram-positive and Gram-negative bacteria, especially for the pyogenic Staphylococcus aureus. Moreover, the hydrogel showed almost no hemolysis and cytotoxicity. In vivo investigations indicated that hydrogels effectively killed S. aureus and protected against deterioration of inflammation. Besides, bioimaging of mice demonstrated that the hydrogel could be completely metabolized within 16 h. In a nutshell, given its outstanding antibacterial property and biocompatibility, the novel hydrogel could be an ideal candidate for the subcutaneous infection application.24:T53b,Modern medicine has increasingly higher requirements for antibacterial materials. To overcome this challenge, we use alkynyl monomers, amino monomers, formaldehyde, and acetic acid as raw materials to synthesize a series of poly-tetrahydropyrimidine (P-THP) polymers through multicomponent polymerizations (MCPs). P-THP polymers can effectively inhibit the growth of Gram-positive bacteria (Staphylococcus aureus, S. aureus) and Gram-negative bacteria (Escherichia. coli, E. coli), and can prevent bacteria from developing drug resistance within at least 16 generations. Besides, we prepared P-THP antibacterial coatings and explored their antibacterial properties. In vitro antibacterial experiments showed that P-THP coatings can prevent the formation of bacterial biofilms, and the coatings have a lasting killing effect on E. coli and S. aureus. The mouse wound infection experiments proved that P-THP polymers can significantly accelerate skin tissue regeneration and wound healing. Moreover, the P-THP textile obtained by electrospinning also has antibacterial properties and has great applica

#	Concept	H-Index	Publications	Citations
1	Engineering	3	3	174
2	Medicine	3	3	174
3	Biomedical Engineering	3	3	174
4	Biomolecular Engineering	1	1	38
5	Microbiology	1	1	52

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