Mitochondrial oxidative metabolism contributes to a cancer stem cell phenotype in cholangiocarcinoma

Chiara Raggi, Maria Letizia Taddei, Elena Sacco, +22

Journal of Hepatology

Cancer MetabolismMitochondrial Oxidative MetabolismMitochondrial FunctionCancer StemMedicine +7

The protease‐inhibitor SerpinB3 as a critical modulator of the stem‐like subset in human cholangiocarcinoma

Margherita Correnti, A. Cappon, Mirella Pastore, +23

Liver International

<i>PCSK9</i> rs11591147 R46L loss‐of‐function variant protects against liver damage in individuals with NAFLD

Stefania Grimaudo, Stefano Bartesaghi, Raffaela Rametta, +18

Liver International

An investigation on 4-thiazolidinone derivatives as dual inhibitors of aldose reductase and protein tyrosine phosphatase 1B, in the search for potential agents for the treatment of type 2 diabetes mellitus and its complications

Rosanna Maccari, Antonella Del Corso, Paolo Paoli, +7

Bioorganic & Medicinal Chemistry Letters

Aldo-keto ReductaseBiochemistryMedicineAldose ReductaseDiabetes +6

Discovery of 4-[(5-arylidene-4-oxothiazolidin-3-yl)methyl]benzoic acid derivatives active as novel potent allosteric inhibitors of protein tyrosine phosphatase 1B: In silico studies and in vitro evaluation as insulinomimetic and anti-inflammatory agents

Rosaria Ottanà, Paolo Paoli, Alexandra Naß, +7

European Journal of Medicinal Chemistry

Medicinal ChemistryAnti-inflammatory AgentsBiochemistryMedicineNatural Sciences +9

Synthesis and evaluation of thiazolidine-2,4-dione/benzazole derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B): Antihyperglycemic activity with molecular docking study

Sergio Hidalgo‐Figueroa, Samuel Estrada‐Soto, Juan José Ramírez‐Espinosa, +4

Biomedicine & Pharmacotherapy

BiochemistryMedicineThiazolidine-2,4-dione/benzazole DerivativesAntihyperglycemic ActivityDrug Development +4

Morin‐dependent inhibition of low molecular weight protein tyrosine phosphatase (LMW‐PTP) restores sensitivity to apoptosis during colon carcinogenesis: Studies in vitro and in vivo, in an <i>Apc</i>‐driven model of colon cancer

Giulia Lori, Paolo Paoli, Angelo Pietro Femia, +6

Molecular Carcinogenesis

Honey extracts inhibit PTP1B, upregulate insulin receptor expression, and enhance glucose uptake in human HepG2 cells

Giulia Lori, Lorenzo Cecchi, Nádia Mulinacci, +7

Biomedicine & Pharmacotherapy

CXCR7 contributes to the aggressive phenotype of cholangiocarcinoma cells

Alessandra Gentilini, Alessandra Caligiuri, Chiara Raggi, +15

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

MedicineBiliary CancerPathologyAggressive PhenotypeCancer Biology +3

Targeting <scp>LMW</scp>‐<scp>PTP</scp> to sensitize melanoma cancer cells toward chemo‐ and radiotherapy

Giulia Lori, Paolo Paoli, Anna Caselli, +6

Cancer Medicine