Genomics and drug profiling of fatal TCF3-HLF−positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options

Ute Fischer, Michael Förster, Anna Maria Rinaldi, +63

Nature Genetics

Therapeutic OptionsTumor BiologyHematological MalignancyMedicineImmunology +6

Combined immunodeficiency with life-threatening EBV-associated lymphoproliferative disorder in patients lacking functional CD27

Elisabeth Salzer, Svenja Daschkey, Sharon Choo, +12

Haematologica

Adaptive Immune SystemImmunodeficienciesFunctional Cd27ImmunologyPathology +16

Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i> -Inherited Susceptibility

Alberto Martín‐Lorenzo, Julia Hauer, Carolina Vicente‐Dueñas, +20

Cancer Discovery

Loss-of-function mutations within the IL-2 inducible kinase ITK in patients with EBV-associated lymphoproliferative diseases

René Martin Linka, Sarah L. Risse, K. Bienemann, +22

Leukemia

Primary ImmunodeficiencyImmunologyEbv-associated Lymphoproliferative DiseasesPathologyAutoimmunity +6

EBV Negative Lymphoma and Autoimmune Lymphoproliferative Syndrome Like Phenotype Extend the Clinical Spectrum of Primary Immunodeficiency Caused by STK4 Deficiency

Cyrill Schipp, David Schlütermann, Andrea Hönscheid, +9

Frontiers in Immunology

STAT3 gain-of-function mutations associated with autoimmune lymphoproliferative syndrome like disease deregulate lymphocyte apoptosis and can be targeted by BH3 mimetic compounds

Schafiq Nabhani, Cyrill Schipp, Hagit Miskin, +14

Clinical Immunology

ImmunogeneticsAllergyAutoimmune DiseaseStat3 Gain-of-function MutationsAutoantibody Production +8

Loss of Pax5 Exploits Sca1-BCR-ABLp190 Susceptibility to Confer the Metabolic Shift Essential for pB-ALL

Alberto Martín‐Lorenzo, Franziska Auer, Lai N. Chan, +18

Cancer Research

Next-generation-sequencing of recurrent childhood high hyperdiploid acute lymphoblastic leukemia reveals mutations typically associated with high risk patients

Cai Chen, Christoph Bartenhagen, Michael Gombert, +14

Leukemia Research

Hematological MalignancyMedicineGeneticsMixed-phenotype Acute LeukemiaHematology +6

The impact of TEL-AML1 (ETV6-RUNX1) expression in precursor B cells and implications for leukaemia using three different genome-wide screening methods

Yvonne Linka, Sebastian Ginzel, Marcus Krüger, +7

Blood Cancer Journal

Hematological MalignancyTumor BiologySystems BiologyEngineeringMedicine +12

Next‐generation‐sequencing‐based risk stratification and identification of new genes involved in structural and sequence variations in near haploid lymphoblastic leukemia

Cai Chen, Christoph Bartenhagen, Michael Gombert, +12

Genes Chromosomes and Cancer

CytogeneticsNear HaploidyGeneticsMixed-phenotype Acute LeukemiaNear Haploid +18