Methyl-Thiazoles: A Novel Mode of Inhibition with the Potential to Develop Novel Inhibitors Targeting InhA in Mycobacterium tuberculosis

Pravin S. Shirude, Prashanti Madhavapeddi, Maruti Naik, +16

Journal of Medicinal Chemistry

Molecular BiologyChemical BiologyEnzymatic ModificationDrug ResistanceMedicinal Chemistry +17

Quinolinyl Pyrimidines: Potent Inhibitors of NDH-2 as a Novel Class of Anti-TB Agents

Pravin S. Shirude, Beena Paul, Nilanjana Roy Choudhury, +3

ACS Medicinal Chemistry Letters

PharmacotherapyChemical BiologyPharmaceutical ChemistryEssential Respiratory EnzymeDrug Resistance +18

Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate

Shahul Hameed P, Suresh Solapure, Vikas Patil, +46

Nature Communications

Discovery of benzothiazoles as antimycobacterial agents: Synthesis, structure–activity relationships and binding studies with Mycobacterium tuberculosis decaprenylphosphoryl-β-d-ribose 2′-oxidase

Sudhir Landge, Amrita B. Mullick, Kavitha Nagalapur, +23

Bioorganic & Medicinal Chemistry

Antimicrobial Drug DiscoveryBiochemistryMedicineMycobacterium TuberculosisTuberculosis +7

Structural and Biochemical Characterization of Compounds Inhibiting Mycobacterium tuberculosis Pantothenate Kinase

C. Bjorkelid, Terese Bergfors, Anand Kumar Raichurkar, +4

Journal of Biological Chemistry

Biomolecular Structure PredictionMolecular BiologyChemical BiologyDrug ResistanceBiosynthesis +16

Diarylthiazole: An Antimycobacterial Scaffold Potentially Targeting PrrB-PrrA Two-Component System

Eknath V. Bellale, Maruti Naik, Varun VB, +17

Journal of Medicinal Chemistry

Medicinal ChemistrySensor Kinase PrrbBioorganic ChemistryPrrba TwoMedicine +13

Structure Guided Lead Generation for <i>M. tuberculosis</i> Thymidylate Kinase (Mtb TMK): Discovery of 3-Cyanopyridone and 1,6-Naphthyridin-2-one as Potent Inhibitors

Maruti Naik, Anandkumar Raichurkar, Balachandra Bandodkar, +19

Journal of Medicinal Chemistry

Drug TargetCyanopyridone SubseriesChemical BiologyPharmaceutical ChemistryDiversity Oriented Synthesis +15

Repositioning: the fast track to new anti-malarial medicines?

Julie Lotharius, Francisco Javier Gamo‐Benito, Íñigo Angulo‐Barturen, +13

Malaria Journal

Aminoazabenzimidazoles, a Novel Class of Orally Active Antimalarial Agents

Shahul Hameed P, Murugan Chinnapattu, Gajanan Shanbag, +40

Journal of Medicinal Chemistry

Pharmaceutical ScienceAntiparasitic AgentMalariaPlasmodium FalciparumPharmaceutical Chemistry +18

Assessment of Mycobacterium tuberculosis Pantothenate Kinase Vulnerability through Target Knockdown and Mechanistically Diverse Inhibitors

B. K. Kishore Reddy, Sudhir Landge, Sudha Ravishankar, +24

Antimicrobial Agents and Chemotherapy

Drug TargetMolecular BiologyTarget KnockdownM. Tuberculosis PankChemical Biology +17