Molecular basis of an autoantibody-associated restriction fragment length polymorphism that confers susceptibility to autoimmune diseases.

T Olee, Pei–Ming Yang, K A Siminovitch, +6

Journal of Clinical Investigation

Disease EtiologyGeneticsImmunologyPathologyImmune System +17

A natural autoantibody is encoded by germline heavy and lambda light chain variable region genes without somatic mutation.

Katherine A. Siminovitch, Virginia L. Misener, Pak C. Kwong, +2

Journal of Clinical Investigation

GeneticsGenomic MechanismMolecular BiologyGene CharacterizationMolecular Genetics +20

A monoclonal IgG anticardiolipin antibody from a patient with the antiphospholipid syndrome is thrombogenic in mice.

T Olee, S S Pierangeli, Harold H. Handley, +8

Proceedings of the National Academy of Sciences

ImmunologyPathologyAntiphospholipid AntibodiesHyperlipidemiaThrombosis +19

The incidence of a new human cross-reactive idiotype linked to subgroup VHIII heavy chains

Joseph J. Crowley, Rizgar A. Mageed, Gregg J. Silverman, +5

Molecular Immunology

Vhiii Heavy ChainsAllelic VariantDisease EtiologyGenetic DisorderGenetics +6

Possible deletion of a developmentally regulated heavy-chain variable region gene in autoimmune diseases.

Pei–Ming Yang, Nancy J. Olsen, K A Siminovitch, +4

Proceedings of the National Academy of Sciences

Disease EtiologyGeneticsImmunologyGenetic EpidemiologyMolecular Genetics +21

A systematic approach to defining the germline gene counterparts of a mutated autoantibody from a patient with rheumatoid arthritis

Rafael W. Soto‐Gil, Tsaiwei Olee, Brenda K. Klink, +4

Arthritis & Rheumatism

Defining the genetic origins of three rheumatoid synovium-derived IgG rheumatoid factors.

Michael Deftos, T Olee, Dennis A. Carson, +1

Journal of Clinical Investigation

GeneticsImmunologyDisease Gene IdentificationRf ProductionImmune-related Gene Polymorphism +16

A highly informative probe for two polymorphic Vh gene regions that contain one or more autoantibody-associated Vh genes.

P P Chen, K A Siminovitch, Nancy J. Olsen, +2

Journal of Clinical Investigation

HistocompatibilityHeavy Chain VGeneticsImmunologyHuman Polymorphism +15

Isolation, characterization and sequence analysis of five IgG monoclonal anti-beta 2-glycoprotein-1 and anti-prothrombin antigen-binding fragments generated by phage display.

Reginald U. Chukwuocha, Elie T. Hsiao, Peter X. Shaw, +2

PubMed

ImmunohematologyProthrombin-isolated MabsImmunologyGlycobiologyAnti-prothrombin Antigen-binding Fragments +18