Manuel A.F.V. Gonçalves

Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells

Maarten Holkers, Ignazio Maggio, Jin Liu et al. · Nucleic Acids Research · 2012 · 304 citations · Full text

Viral Replication, Genetics, Immunology +20

Probing the impact of chromatin conformation on genome editing tools

Xiaoyu Chen, Marrit Rinsma, Josephine M. Janssen et al. · Nucleic Acids Research · 2016 · 147 citations · Full text

Genetics, Molecular Biology, Epigenetics +18

Adenoviral vector delivery of RNA-guided CRISPR/Cas9 nuclease complexes induces targeted mutagenesis in a diverse array of human cells

Ignazio Maggio, Maarten Holkers, Jin Liu et al. · Scientific Reports · 2014 · 143 citations · Full text

Adenoviral vector DNA for accurate genome editing with engineered nucleases

Maarten Holkers, Ignazio Maggio, Sara F. Henriques et al. · Nature Methods · 2014 · 134 citations

Engineering, Oligonucleotide, Genetic Engineering +8

In trans paired nicking triggers seamless genome editing without double-stranded DNA cutting

Xiaoyu Chen, Josephine M. Janssen, Jin Liu et al. · Nature Communications · 2017 · 90 citations · Full text