Matthew J. Irby

Structural basis for Cas9 off-target activity

Martin Pacesa, Chun‐Han Lin, Antoine Cléry et al. · Cell · 2022 · 201 citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Harnessing type I CRISPR–Cas systems for genome engineering in human cells

Peter Cameron, Mary Coons, Sanne E. Klompe et al. · Nature Biotechnology · 2019 · 123 citations

Life Sciences, Genetics, Molecular Genetics +14

Conformational control of Cas9 by CRISPR hybrid RNA-DNA guides mitigates off-target activity in T cells

Paul D. Donohoue, Martin Pačesa, Elaine K. Lau et al. · Molecular Cell · 2021 · 67 citations · Full text

Life Sciences, Biotechnology, Molecular Biology +11

High-Specificity CRISPR-Mediated Genome Engineering in Anti-BCMA Allogeneic CAR T Cells Suppresses Allograft Rejection in Preclinical Models

Émilie Degagné, Paul D. Donohoue, Suparna Roy et al. · Cancer Immunology Research · 2024 · 32 citations · Full text

Life Sciences, Biotechnology, Immunology +17

Generation of a Commercial-Scale Founder Population of Porcine Reproductive and Respiratory Syndrome Virus Resistant Pigs Using CRISPR-Cas

Brian T. Burger, Benjamin P. Beaton, Matthew A. Campbell et al. · The CRISPR Journal · 2024 · 32 citations · Full text

Agriculture, Biotechnology, Genetics +17