ARID1A Maintains Differentiation of Pancreatic Ductal Cells and Inhibits Development of Pancreatic Ductal Adenocarcinoma in Mice

Yoshito Kimura, Akihisa Fukuda, Satoshi Ogawa, +16

Gastroenterology

Pancreatic Ductal CellsDevelopmental BiologyPancreatic CancerMedicineCancer Cell Biology +9

THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer

Mayuki Omatsu, Yuki Nakanishi, Kosuke Iwane, +40

Nature Communications

Lineage tracing and targeting of IL17RB ⁺ tuft cell-like human colorectal cancer stem cells

Norihiro Goto, Akihisa Fukuda, Yuichi Yamaga, +10

Proceedings of the National Academy of Sciences

Chemical evolution of primordial salts and organic sulfur molecules in the asteroid 162173 Ryugu

Toshihiro Yoshimura, Yoshinori Takano, Hiroshi Naraoka, +40

Nature Communications

Pancreatic RECK inactivation promotes cancer formation, epithelial-mesenchymal transition, and metastasis

Tomonori Masuda, Akihisa Fukuda, Go Yamakawa, +20

Journal of Clinical Investigation

Pancreatic Reck InactivationTumor BiologyHuman PdacPancreatic CancerMedicine +10

SETDB1 Inhibits p53-Mediated Apoptosis and Is Required for Formation of Pancreatic Ductal Adenocarcinomas in Mice

Satoshi Ogawa, Akihisa Fukuda, Y Matsumoto, +17

Gastroenterology

Loss of Arid1a and Pten in Pancreatic Ductal Cells Induces Intraductal Tubulopapillary Neoplasm via the YAP/TAZ Pathway

Yuichi Fukunaga, Akihisa Fukuda, Mayuki Omatsu, +17

Gastroenterology

Signal TransductionSignaling PathwayPancreatic CancerCell SignalingPathology +5

Epithelial EP4 plays an essential role in maintaining homeostasis in colon

Y Matsumoto, Yuki Nakanishi, Takuto Yoshioka, +13

Scientific Reports

Nardilysin controls intestinal tumorigenesis through HDAC1/p53–dependent transcriptional regulation

Keitaro Kanda, Jiro Sakamoto, Y Matsumoto, +19

JCI Insight

Nuclear NrdcOncologyGastrointestinal OncologyEpigenetic RegulationMedicine +12

Brg1 controls stemness and metastasis of pancreatic cancer through regulating hypoxia pathway

Osamu Araki, Motoyuki Tsuda, Mayuki Omatsu, +19

Oncogene