A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids

Liuliu Yang, Yuling Han, Benjamin E. Nilsson-Payant, +34

Cell stem cell

Induced Pluripotent Stem CellHuman CellsViral PathogenesisVirologyStem Cell Research +5

Identification of SARS-CoV-2 inhibitors using lung and colonic organoids

Yuling Han, Xiaohua Duan, Liuliu Yang, +31

Nature

MedicineColonic OrganoidsAntiviral Drug DevelopmentAntiviral DrugPharmacology +2

Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine

Luís Felipe Campesato, Sadna Budhu, Jeremy H. Tchaicha, +15

Nature Communications

ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity

John A. Moral, Joanne Leung, Luis A. Rojas, +18

Nature

Tumor ImmunologyCancer ImmunosurveillanceTissue-specific Cancer ImmunityImmunologyTumor Immunity +4

T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants

Daniel Hirschhorn, Sadna Budhu, Lukas Kraehenbuehl, +31

Cell

Tumor ImmunologyCancer ImmunosurveillanceAutoimmune DiseaseImmunologyTumor Immunity +9

Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis

Brisa Palikuqi, Duc-Huy T. Nguyen, Ge Li, +26

Nature

AngiogenesisVascular AdaptationVascular BiologyNeovascularizationMedicine +5

Conversion of adult endothelium to immunocompetent haematopoietic stem cells

Raphaël Lis, Charles Karrasch, Michael G. Poulos, +15

Nature

Cell TherapyHaematopoietic Stem CellsMedicineStem Cell MobilizationImmunology +6

Pluripotent stem cell-derived epithelium misidentified as brain microvascular endothelium requires ETS factors to acquire vascular fate

Tyler M. Lu, Sean Houghton, Tarig Magdeldin, +13

Proceedings of the National Academy of Sciences

Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2

Moritz Reiterer, Mangala Rajan, Nicolás Gómez-Banoy, +25

Cell Metabolism

Insulin ResistanceMetabolic SyndromeAdipose Tissue InfectivityAcute Covid-19Global Health +8

EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop

Wendy Béguelin, Martín A. Rivas, María Teresa Calvo, +8

Nature Communications