CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity

Naoto Fujiwara, Hayato Nakagawa, Kenichiro Enooku, +19

Gut

GPR30-Expressing Gastric Chief Cells Do Not Dedifferentiate But Are Eliminated via PDK-Dependent Cell Competition During Development of Metaplasia

Masahiro Hata, Hiroto Kinoshita, Yoku Hayakawa, +16

Gastroenterology

Developmental BiologyCell RegulationCell SignalingMedicineCell Proliferation +7

Mature gastric chief cells are not required for the development of metaplasia

Hiroto Kinoshita, Yoku Hayakawa, Zhengchuan Niu, +10

American Journal of Physiology-Gastrointestinal and Liver Physiology

Three types of metaplasia model through <i>Kras</i> activation, <i>Pten</i> deletion, or <i>Cdh1</i> deletion in the gastric epithelium

Hiroto Kinoshita, Yoku Hayakawa, Mitsuru Konishi, +11

The Journal of Pathology

Cell fate analysis of zone 3 hepatocytes in liver injury and tumorigenesis

Shigeyuki Kurosaki, Hayato Nakagawa, Yuki Hayata, +14

JHEP Reports

Discovery of a Vitamin D Receptor-Silent Vitamin D Derivative That Impairs Sterol Regulatory Element-Binding Protein In Vivo

Fumihiro Kawagoe, Aileen Mendoza, Yuki Hayata, +11

Journal of Medicinal Chemistry

Axin2+ Peribiliary Glands in the Periampullary Region Generate Biliary Epithelial Stem Cells That Give Rise to Ampullary Carcinoma

Yuki Hayata, Hayato Nakagawa, Shigeyuki Kurosaki, +16

Gastroenterology

Post-treatment cell-free DNA as a predictive biomarker in molecular-targeted therapy of hepatocellular carcinoma

T. Nakatsuka, Hayato Nakagawa, Yuki Hayata, +14

Journal of Gastroenterology

Molecular-targeted TherapyMedicinePathologyCancer GenomicsPost-treatment Cell-free Dna +8

Potential Effectiveness of Tolvaptan to Improve Ascites Unresponsive to Standard Diuretics and Overall Survival in Patients with Decompensated Liver Cirrhosis

Tomoharu Yamada, Takamasa Ohki, Yuki Hayata, +7

Clinical Drug Investigation

Standard DiureticsHepatologyMedicineLiver PhysiologyHepatitis +9

Karyotyping of Female and Male Hediste japonica (Polychaeta, Annelida) in Comparison with Those of Two Closely Related Species, H. diadroma and H. atoka

Hiroaki Tosuji, Junko Miyamoto, Yuki Hayata, +1

ZOOLOGICAL SCIENCE