OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

Young‐Yun Kong, Hiroki Yoshida, Ildiko Sarosi, +14

Nature

Developmental BiologyKey RegulatorBone Morphogenic ProteinCell SignalingLymphocyte Development +9

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

Mark Lomaga, Wen‐Chen Yeh, Ildiko Sarosi, +20

Genes & Development

Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration

Takehiko Sasaki, Junko Irie-Sasaki, Russell G. Jones, +12

Science

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

Nobutaka Suzuki, Shinobu Suzuki, Gordon S. Duncan, +12

Nature

InflammationToll-like ReceptorsCytokineAutoimmune DiseaseImmunology +8

ICOS is essential for effective T-helper-cell responses

Arda Shahinian, Friedhelm Bladt, Steve K. Yoshinaga, +15

Nature

Adaptive Immune SystemT-regulatory CellImmunologyAutoimmunitySelf-tolerance +6

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

Kurt Bachmaier, Connie M. Krawczyk, I. Kozieradzki, +13

Nature

InflammationLymphocyte ActivationMolecular Adaptor Cbl-bAllergyAutoimmune Disease +10

The B7 family member B7-H3 preferentially down-regulates T helper type 1–mediated immune responses

Woong‐Kyung Suh, Beata Gajewska, Hitoshi Okada, +21

Nature Immunology

InflammationAllergyAdaptive Immune SystemImmune Cell DevelopmentImmunology +11

Requirement for Casper (c-FLIP) in Regulation of Death Receptor–Induced Apoptosis and Embryonic Development

Wen‐Chen Yeh, Annick Itié, Andrew Elia, +8

Immunity

Signal TransductionDevelopmental BiologySignaling PathwayCell RegulationMedicine +7

The tumor suppressor gene <i>Smad4/Dpc4</i> is required for gastrulation and later for anterior development of the mouse embryo

Christian Sirard, José Luís de la Pompa, Andrew Elia, +9

Genes & Development

Impaired Bone Marrow Microenvironment and Immune Function in T Cell Protein Tyrosine Phosphatase–deficient Mice

Kong Eric You-Ten, Eric S. Muise, Annick Itié, +5

The Journal of Experimental Medicine