Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

Jeremy Schwartzentruber, Andrey Korshunov, Xiao-Yang Liu, +59

Nature

ChromatinNeuro-oncologyChromatin StructureGliomaDriver Mutations +11

Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

Dominik Sturm, Hendrik Witt, Volker Hovestadt, +75

Cancer Cell

Neuro-oncologyRadiation OncologySomatic VariantTumor HeterogeneityGenetics +9

K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas

Dong-Anh Khuong-Quang, Pawel Buczkowicz, Patricia Rakopoulos, +24

Acta Neuropathologica

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

David Jones, Barbara Hutter, Natalie Jäger, +70

Nature Genetics

Neuro-oncologyMolecular NeuroscienceGliomaPathologyMolecular Pathology +5

Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma

Adam M. Fontebasso, Simon Papillon‐Cavanagh, Jeremy Schwartzentruber, +45

Nature Genetics

Neuro-oncologyDevelopmental BiologyPediatric Brain TumorsGeneticsRecurrent Somatic Mutations +4

Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations

Xiaoyang Liu, Noha Gerges, Andrey Korshunov, +19

Acta Neuropathologica

Somatic VariantGliomaPathologyTp53 MutationsFrequent Atrx Mutations +5

H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis

Ashot S. Harutyunyan, Brian Krug, Haifeng Chen, +30

Nature Communications

Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas

Adam M. Fontebasso, Jeremy Schwartzentruber, Dong-Anh Khuong-Quang, +26

Acta Neuropathologica

Epigenetic ChangeGeneticsPathologyDisease Gene IdentificationHigh-grade Gliomas +17

Stalled developmental programs at the root of pediatric brain tumors

Selin Jessa, Alexis Blanchet-Cohen, Brian Krug, +37

Nature Genetics

Neuro-oncologyPediatric Brain TumorsDevelopmental BiologyBrain DevelopmentPediatrics +8

Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma

Hamid Nikbakht, Eshini Panditharatna, Leonie G. Mikael, +21

Nature Communications