Clemens Krepler

Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance

Sydney M. Shaffer, Margaret C. Dunagin, Stefan Torborg et al. · Nature · 2017 · 1.3K citations

Oncology, Health Sciences, Cancer Drug Resistance +11

Pembrolizumab versus ipilimumab in advanced melanoma (KEYNOTE-006): post-hoc 5-year results from an open-label, multicentre, randomised, controlled, phase 3 study

Caroline Robert, Antoni Ribas, Jacob Schachter et al. · The Lancet Oncology · 2019 · 1.1K citations

Medicine, Melanoma, Immunology +9

Overcoming Intrinsic Multidrug Resistance in Melanoma by Blocking the Mitochondrial Respiratory Chain of Slow-Cycling JARID1Bhigh Cells

Alexander Roesch, Adina Vultur, Ivan Bogeski et al. · Cancer Cell · 2013 · 662 citations · Full text

Mitochondrial Respiratory Chain, Tumor Biology, Intrinsic Multidrug Resistance +11

Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy

Ying Zhang, Raj K. Kurupati, Ling Liu et al. · Cancer Cell · 2017 · 583 citations · Full text

Cancer Immunosurveillance, Immunology, Biological Microenvironments +8

Association Between Immune-Related Adverse Events and Recurrence-Free Survival Among Patients With Stage III Melanoma Randomized to Receive Pembrolizumab or Placebo

Alexander M.M. Eggermont, Michal Kiciński, Christian U. Blank et al. · JAMA Oncology · 2020 · 421 citations · Full text