In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)

Nobumichi Ohoka, Keiichiro Okuhira, Masahiro Ito, +14

Journal of Biological Chemistry

Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands

Norihito Shibata, Katsunori Nagai, Yoko Morita, +9

Journal of Medicinal Chemistry

Androgen ReceptorChemoprevention StrategyApoptosisCell DeathApoptosis Protein Ligands +18

TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma

Kazuhide Nakayama, Magdalena M. Szewczyk, Carlo dela Seña, +21

Oncotarget

Discovery of Potent Mcl-1/Bcl-xL Dual Inhibitors by Using a Hybridization Strategy Based on Structural Analysis of Target Proteins

Yuta Tanaka, Katsuji Aikawa, Goushi Nishida, +13

Journal of Medicinal Chemistry

Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation

Nobumichi Ohoka, Yoko Morita, Katsunori Nagai, +15

Journal of Biological Chemistry

Development of protein degradation inducers of oncogenic <scp>BCR</scp>‐<scp>ABL</scp> protein by conjugation of <scp>ABL</scp> kinase inhibitors and <scp>IAP</scp> ligands

Norihito Shibata, Naoki Miyamoto, Katsunori Nagai, +8

Cancer Science

Discovery of 3-Benzyl-1-(<i>trans</i>-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12) Inhibitors

Masahiro Ito, Toshio Tanaka, Akinori Toita, +16

Journal of Medicinal Chemistry

Discovery of a B-Cell Lymphoma 6 Protein–Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach

Yusuke Kamada, Nozomu Sakai, Satoshi Sogabe, +9

Journal of Medicinal Chemistry

A model of antimycin A binding based on structure-activity studies of synthetic antimycin A analogues

Hideto Miyoshi, Nobuya Tokutake, Yasuhiro Imaeda, +2

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Medicinal ChemistryBioorganic ChemistrySynthetic AntimycinBiochemistryNatural Sciences +9

Discovery of a Tetrahydropyrimidin-2(1<i>H</i>)-one Derivative (TAK-442) as a Potent, Selective, and Orally Active Factor Xa Inhibitor

Takuya Fujimoto, Yasuhiro Imaeda, Noriko Konishi, +5

Journal of Medicinal Chemistry

Pharmaceutical SciencePharmacotherapyActive Fxa InhibitorChemical BiologyPharmaceutical Chemistry +14