(2<i>R</i>)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-<i>a</i>]pyrazin- 7(8<i>H</i>)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine:  A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

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Journal of Medicinal Chemistry

A Single <i>IGF1</i> Allele Is a Major Determinant of Small Size in Dogs

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Science

GeneticsGenomic SelectionAnimal GeneticsGenotype-phenotype AssociationMolecular Ecology +16

Dipeptidyl Peptidase IV Inhibition for the Treatment of Type 2 Diabetes

George R. Lankas, Barbara Leiting, Ranabir Sinha Roy, +23

Diabetes

Diabetes ManagementPharmacological StudyBiochemistryDiabetesPharmacology +13

Chronic Inhibition of Dipeptidyl Peptidase-4 With a Sitagliptin Analog Preserves Pancreatic β-Cell Mass and Function in a Rodent Model of Type 2 Diabetes

James Mu, John Woods, Yun-Ping Zhou, +10

Diabetes

Dipeptidyl Peptidase-4Insulin SignalingGastrointestinal Peptide HormoneObesityMetabolic Syndrome +15

Glucagon-Like Peptide 1/Glucagon Receptor Dual Agonism Reverses Obesity in Mice

Alessandro Pocai, Paul E. Carrington, Jennifer R. Adams, +21

Diabetes

Simultaneous inference of selection and population growth from patterns of variation in the human genome

Scott Williamson, Ryan D. Hernandez, Adi Fledel-Alon, +3

Proceedings of the National Academy of Sciences

Demographic ForcesGeneticsPopulation DynamicNatural SelectionGenomic Selection +15

Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance

Stacey Conarello, Zhihua Li, John Ronan, +9

Proceedings of the National Academy of Sciences

The Role of Dipeptidyl Peptidase IV in the Cleavage of Glucagon Family Peptides

Lan Zhu, Constantin Tamvakopoulos, Dan Xie, +8

Journal of Biological Chemistry

Glucagon receptor knockout mice are resistant to diet-induced obesity and streptozotocin-mediated beta cell loss and hyperglycaemia

Stacey Conarello, Guoqiang Jiang, James Mu, +9

Diabetologia

ObesityMetabolic SyndromeEnergy HomeostasisMedicinePhysiology +9

Linkage Disequilibrium and Demographic History of Wild and Domestic Canids

Melissa Gray, Julie M. Granka, Carlos D. Bustamante, +5

Genetics

GeneticsWildlife BiologyPopulation EcologyAnimal GeneticsMolecular Ecology +16