The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets

Thomas P. Peacock, Daniel H. Goldhill, Jie Zhou, +16

Nature Microbiology

Developmental BiologySignal TransductionViral PathogenesisSars-cov-2 Spike ProteinVirology +6

The altered entry pathway and antigenic distance of the SARS-CoV-2 Omicron variant map to separate domains of spike protein

Thomas P. Peacock, Jonathan C. Brown, Jie Zhou, +16

Viral PathogenesisImmunologyImmunodominanceSpike GeneDelta Variant +17

Clinical and laboratory evaluation of SARS-CoV-2 lateral flow assays for use in a national COVID-19 seroprevalence survey

Barnaby Flower, Jonathan C. Brown, Bryony Simmons, +34

Thorax

The furin cleavage site of SARS-CoV-2 spike protein is a key determinant for transmission due to enhanced replication in airway cells

Thomas P. Peacock, Daniel H. Goldhill, Jie Zhou, +16

Viral ReplicationVirus EntryViral PathogenesisImmunologyCell Surface Protease +18

Increased transmission of SARS-CoV-2 lineage B.1.1.7 (VOC 2020212/01) is not accounted for by a replicative advantage in primary airway cells or antibody escape

Jonathan C. Brown, Daniel H. Goldhill, Jie Zhou, +11

Viral ReplicationViral ImmunityViral PathogenesisImmunologyImmunodominance +17

SARS-CoV-2 lateral flow assays for possible use in national covid-19 seroprevalence surveys (React 2): diagnostic accuracy study

Maya Moshe, Anna Daunt, Barnaby Flower, +35

BMJ

Mutations that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway

Jie Zhou, Thomas P. Peacock, Jonathan C. Brown, +25

Cell Reports

Ferret AdaptationHuman AirwayViral PathogenesisImmunologyPathology +14

Diffuse White Matter Signal Abnormalities on Magnetic Resonance Imaging Are Associated With Human Immunodeficiency Virus Type 1 Viral Escape in the Central Nervous System Among Patients With Neurological Symptoms

Ruthiran Kugathasan, Dami A. Collier, Lewis Haddow, +5

Clinical Infectious Diseases

Deep mutagenesis scanning using whole trimeric SARS-CoV-2 spike highlights the importance of NTD-RBD interactions in determining spike phenotype

Ruthiran Kugathasan, Ksenia Sukhova, Maya Moshe, +1

PLoS Pathogens

Whole Trimeric SpikeImmunologyMolecular BiologyViral Structural ProteinImmunotherapy +18

A self-amplifying RNA vaccine protects against SARS-CoV-2 (D614G) and Alpha variant of concern (B.1.1.7) in a transmission-challenge hamster model

Rebecca Frise, Laury Baillon, Jie Zhou, +6

Vaccine