Michael W. Heartlein

Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs

Kevin Kauffman, J. Robert Dorkin, Jung Hoon Yang et al. · Nano Letters · 2015 · 738 citations

Tissue Engineering, Nanomedicine, Nanoparticles +15

Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium

Asha K. Patel, James C. Kaczmarek, Suman Bose et al. · Advanced Materials · 2019 · 364 citations · Full text

Polymer–Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs

James C. Kaczmarek, Asha K. Patel, Kevin Kauffman et al. · Angewandte Chemie International Edition · 2016 · 316 citations · Full text

Nanoparticles, Nanomedicine, Polymer–lipid Nanoparticles +13

Synthesis and Biological Evaluation of Ionizable Lipid Materials for the In Vivo Delivery of Messenger RNA to B Lymphocytes

Owen S. Fenton, Kevin Kauffman, James C. Kaczmarek et al. · Advanced Materials · 2017 · 273 citations

Engineering, Ionizable Lipid Materials, Lnp Composition +19

Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery

Owen S. Fenton, Kevin Kauffman, Rebecca L. McClellan et al. · Advanced Materials · 2016 · 233 citations · Full text

Lipid Preparation, Nanomedicine, Engineering +15