De Novo Initiation of RNA Synthesis by the RNA-Dependent RNA Polymerase (NS5B) of Hepatitis C Virus

Guangxiang Luo, Robert Hamatake, Danielle M. Mathis, +4

Journal of Virology

Viral ReplicationHepatitis C VirusViral Polymerase MechanismImmunologyMolecular Biology +17

Discovery and Preclinical Characterization of the Cyclopropylindolobenzazepine BMS-791325, A Potent Allosteric Inhibitor of the Hepatitis C Virus NS5B Polymerase

Robert G. Gentles, Min Ding, John A. Bender, +43

Journal of Medicinal Chemistry

Development of a Cell-Based High-Throughput Specificity Screen Using a Hepatitis C Virus-Bovine Viral Diarrhea Virus Dual Replicon Assay

Donald R. O’Boyle, Peter T. Nower, Julie A. Lemm, +5

Antimicrobial Agents and Chemotherapy

Comparison of Daclatasvir Resistance Barriers on NS5A from Hepatitis C Virus Genotypes 1 to 6: Implications for Cross-Genotype Activity

Chunfu Wang, Lingling Jia, Donald R. O’Boyle, +9

Antimicrobial Agents and Chemotherapy

Preclinical Characterization of BMS-791325, an Allosteric Inhibitor of Hepatitis C Virus NS5B Polymerase

Julie A. Lemm, Mengping Liu, Robert G. Gentles, +14

Antimicrobial Agents and Chemotherapy

Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A

Jin-Hua Sun, Donald R. O’Boyle, Robert A. Fridell, +19

Nature

Viral HepatitisMedicineAntiviral Drug DevelopmentAntiviral TherapyHepatitis +6

Syntheses and initial evaluation of a series of indolo-fused heterocyclic inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus

Xiaofan Zheng, Thomas W. Hudyma, Scott Martin, +25

Bioorganic & Medicinal Chemistry Letters

BiochemistryHepatitis C VirusViral HepatitisMedicinePolymerase Enzyme +9

Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies

Kap‐Sun Yeung, Brett R. Beno, Kyle Parcella, +34

Journal of Medicinal Chemistry

Hepatitis C VirusImmunologyMolecular BiologyNs5b ReplicaseAntiviral Drug +15

Ligand-induced changes in hepatitis C virus NS5B polymerase structure

Karen Rigat, Yi Wang, Thomas W. Hudyma, +6

Antiviral Research

Virus StructureViral ReplicationViral Polymerase StructureLigand-induced ChangesViral Hepatitis +5

The synthesis of novel heteroaryl-fused 7,8,9,10-tetrahydro-6H-azepino[1,2-a]indoles, 4-oxo-2,3-dihydro-1H-[1,4]diazepino[1,7-a]indoles and 1,2,4,5-tetrahydro-[1,4]oxazepino[4,5-a]indoles. Effective inhibitors of HCV NS5B polymerase

Min Ding, Feng He, Michael A. Poss, +7

Organic & Biomolecular Chemistry

Bioorganic ChemistryHepatitis C VirusSynthetic VirologyMolecular BiologyOrganic Chemistry +17