Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies

Wei Zhou, Jonas B. Nielsen, Lars G. Fritsche, +16

Nature Genetics

Genome-wide Association StudyGenetic AnalysisCase-control ImbalanceGenotype-phenotype AssociationGenetics +9

Biobank-driven genomic discovery yields new insight into atrial fibrillation biology

Jonas B. Nielsen, Rósa B. Þórólfsdóttir, Lars G. Fritsche, +46

Nature Genetics

CardiomyopathyFunctional GenomicsEngineeringTranslational BioinformaticsGenetics +10

Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies

Wei Zhou, Jonas B. Nielsen, Lars G. Fritsche, +16

Case-control ImbalanceGeneticsGenetic EpidemiologyGenetic FoundationGenome-wide Association Studies +20

Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve

Bo Yang, Wei Zhou, Jiao Jiao, +41

Nature Communications

Construction of habitat-specific training sets to achieve species-level assignment in 16S rRNA gene datasets

Isabel F. Escapa, Yanmei Huang, Tsute Chen, +4

Microbiome

Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development

Jonas B. Nielsen, Lars G. Fritsche, Wei Zhou, +41

The American Journal of Human Genetics

CardiomyopathyDevelopmental BiologyHighlights Biological PathwaysGeneticsGenome-wide Study +8

Effects of short indels on protein structure and function in human genomes

Maoxuan Lin, Sarah Whitmire, Jing Chen, +3

Scientific Reports

GeneticsGenomic MechanismMolecular BiologyGene CharacterizationMolecular Genetics +21

Clinical Implications of Identifying Pathogenic Variants in Individuals With Thoracic Aortic Dissection

Brooke N. Wolford, Whitney Hornsby, Dongchuan Guo, +21

Circulation Genomic and Precision Medicine

New insights into protein–DNA binding specificity from hydrogen bond based comparative study

Maoxuan Lin, Jun‐tao Guo

Nucleic Acids Research

DNA hypomethylation silences anti-tumor immune genes in early prostate cancer and CTCs

Hongshan Guo, Joanna Vuille, Ben S. Wittner, +19

Cell

EngineeringEpigenetic ChangeImmunologyPathologyAnti-tumor Immune Genes +17