Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position -7007 of the FPN1 promoter

Samuele Marro, Deborah Chiabrando, Erika Messana, +4

Haematologica

Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease

Francesca Vinchi, Milene Costa da Silva, Giada Ingoglia, +6

Blood

Hemopexin Therapy Improves Cardiovascular Function by Preventing Heme-Induced Endothelial Toxicity in Mouse Models of Hemolytic Diseases

Francesca Vinchi, Lucia De Franceschi, Alessandra Ghigo, +6

Circulation

The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation

Deborah Chiabrando, Samuele Marro, Sonia Mercurio, +12

Journal of Clinical Investigation

GeneticsCell DeathMolecular GeneticsMitochondrial BiologyRedox Biology +16

Intravascular hemolysis activates complement via cell-free heme and heme-loaded microvesicles

Nicolas S. Merle, Anne Grünenwald, Helena Rajaratnam, +23

JCI Insight

Defective Recovery and Severe Renal Damage After Acute Hemolysis in Hemopexin-Deficient Mice

Emanuela Tolosano, Emilio Hirsch, Enrico Patrucco, +4

Blood

Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis

Emanuela Tolosano, Sharmila Fagoonee, Emilio Hirsch, +4

Blood

IL-22 controls iron-dependent nutritional immunity against systemic bacterial infections

Kei Sakamoto, Yun‐Gi Kim, Hideki Hara, +7

Science Immunology

Hemopexin Prevents Endothelial Damage and Liver Congestion in a Mouse Model of Heme Overload

Francesca Vinchi, Stefania Gastaldi, Lorenzo Silengo, +2

American Journal Of Pathology

InflammationLiver PhysiologyPhysiologyHematologyImmunology +12

Plasma Protein Haptoglobin Modulates Renal Iron Loading

Sharmila Fagoonee, Jakub Gburek, Emilio Hirsch, +7

American Journal Of Pathology

Iron DeficiencyRenal FunctionIron MetabolismMedicinePhysiology +3