Elaine Ginn

Identification of <i>N</i>-(4-((1<i>R</i>,3<i>S</i>,5<i>S</i>)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies

Matthew T. Burger, Gisele Nishiguchi, Wooseok Han et al. · Journal of Medicinal Chemistry · 2015 · 76 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Discovery of Potent and Selective Non-Nucleotide Small Molecule Inhibitors of CD73

Joel W. Beatty, Erick A. Lindsey, Rhiannon Thomas‐Tran et al. · Journal of Medicinal Chemistry · 2020 · 56 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +11

Targeting CD73 with AB680 (Quemliclustat), a Novel and Potent Small-Molecule CD73 Inhibitor, Restores Immune Functionality and Facilitates Antitumor Immunity

Dana Piovesan, Joanne B.L. Tan, Annette Becker et al. · Molecular Cancer Therapeutics · 2022 · 41 citations · Full text

Medicine, Immunology, Oncology +17

Discovery of Potent and Selective PI3Kγ Inhibitors

Samuel L. Drew, Rhiannon Thomas‐Tran, Joel W. Beatty et al. · Journal of Medicinal Chemistry · 2020 · 39 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of Potent and Selective 7-Azaindole Isoindolinone-Based PI3Kγ Inhibitors

Dillon H. Miles, Xuelei Yan, Rhiannon Thomas‐Tran et al. · ACS Medicinal Chemistry Letters · 2020 · 21 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13