Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity

Ludmila Pawlikowska, Donglei Hu, Scott Huntsman, +14

Aging Cell

AgingGeneticsGenetic EpidemiologyHuman PolymorphismBiogerontology +23

Temporal Dissection of Tumorigenesis in Primary Cancers

Steffen Durinck, Christine Ho, Nicholas J. Wang, +28

Cancer Discovery

A hybrid approach for de novo human genome sequence assembly and phasing

Yulia Mostovoy, Michal Levy‐Sakin, Jessica Lam, +13

Nature Methods

HybridizationGeneticsHybrid ApproachNatural SciencesSequence Analysis +9

Genome maps across 26 human populations reveal population-specific patterns of structural variation

Michal Levy‐Sakin, Steven Pastor, Yulia Mostovoy, +23

Nature Communications

Genome-Wide Structural Variation Detection by Genome Mapping on Nanochannel Arrays

Angel C. Y. Mak, Yvonne Y. Y. Lai, Ernest T. Lam, +26

Genetics

Effects of the Absence of Apolipoprotein E on Lipoproteins, Neurocognitive Function, and Retinal Function

Angel C. Y. Mak, Clive R. Pullinger, Ling Tang, +19

JAMA Neurology

GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2

Zhiwei Li, Beicheng Sun, Ting Gong, +41

Gastroenterology

InflammationCytokineIl6 SignalingImmunologyChronic Inflammation +6

Manitoba-oculo-tricho-anal (MOTA) syndrome is caused by mutations in <i>FREM1</i>

Anne Slavotinek, Sergio E. Baranzini, Denny Schanze, +16

Journal of Medical Genetics

Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations

Neil N. Trivedi, Bani Tamraz, Catherine Chu, +2

Journal of Allergy and Clinical Immunology

AllergyDisease MechanismGenetic DisorderMast Cell DisorderGenetics +10

Mitochondrial DNA Sequence Variation and Risk of Pancreatic Cancer

Ernest T. Lam, Paige M. Bracci, Elizabeth A. Holly, +7

Cancer Research