Hannah M. Yamagata

High-throughput and high-content bioassay enables tuning of polyester nanoparticles for cellular uptake, endosomal escape, and systemic in vivo delivery of mRNA

Yuan Rui, David R. Wilson, Stephany Y. Tzeng et al. · Science Advances · 2022 · 152 citations · Full text

Pharmacy, Biotechnology, Pharmaceutics +17

Poly(Beta-Amino Ester) Nanoparticles Enable Nonviral Delivery of CRISPR-Cas9 Plasmids for Gene Knockout and Gene Deletion

Yuan Rui, Mahita Varanasi, Shanelle Mendes et al. · Molecular Therapy — Nucleic Acids · 2020 · 69 citations · Full text

Life Sciences, Biotechnology, Molecular Biology +17

Machine learning guided structure function predictions enable in silico nanoparticle screening for polymeric gene delivery

Dennis Gong, Elana Ben‐Akiva, Arshdeep Singh et al. · Acta Biomaterialia · 2022 · 54 citations · Full text

Pharmacy, Biotechnology, Molecular Pharmaceutics +16

Branched endosomal disruptor (BEND) lipids mediate delivery of mRNA and CRISPR-Cas9 ribonucleoprotein complex for hepatic gene editing and T cell engineering

Marshall S. Padilla, Kaitlin Mrksich, Yiming Wang et al. · Nature Communications · 2025 · 46 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Optimized microfluidic formulation and organic excipients for improved lipid nanoparticle mediated genome editing

Rohan Palanki, Emily L. Han, Amanda M. Murray et al. · Lab on a Chip · 2024 · 18 citations · Full text

Life Sciences, Biotechnology, Molecular Genetics +17