Christian Thoma

Trial of Spesolimab for Generalized Pustular Psoriasis

H. Bachelez, Siew Eng Choon, Slaheddine Marrakchi et al. · New England Journal of Medicine · 2021 · 337 citations · Full text

Medicine, Dermatology, Pharmacotherapy +15

Spesolimab, an Anti-Interleukin-36 Receptor Antibody, in Patients with Palmoplantar Pustulosis: Results of a Phase IIa, Multicenter, Double-Blind, Randomized, Placebo-Controlled Pilot Study

Ulrich Mrowietz, A. David Burden, Andreas Pinter et al. · Dermatology and Therapy · 2021 · 93 citations · Full text

Medicine, Dermatology, Pharmacotherapy +16

Pustular psoriasis: Molecular pathways and effects of spesolimab in generalized pustular psoriasis

Patrick Baum, Sudha Visvanathan, Sandra Garcet et al. · Journal of Allergy and Clinical Immunology · 2021 · 86 citations · Full text

Medicine, Dermatology, Immunology +16

Study protocol of the global Effisayil 1 Phase II, multicentre, randomised, double-blind, placebo-controlled trial of spesolimab in patients with generalized pustular psoriasis presenting with an acute flare

Siew Eng Choon, Mark Lebwohl, Slaheddine Marrakchi et al. · BMJ Open · 2021 · 75 citations · Full text

Medicine, Dermatology, Pharmacotherapy +12

Design of Effisayil™ 2: A Randomized, Double-Blind, Placebo-Controlled Study of Spesolimab in Preventing Flares in Patients with Generalized Pustular Psoriasis

Akimichi Morita, Siew Eng Choon, H. Bachelez et al. · Dermatology and Therapy · 2022 · 31 citations · Full text

Medicine, Dermatology, Pharmacotherapy +17