Perry Kennedy

GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors

Aslamuzzaman Kazi, Shengyan Xiang, Hua Yang et al. · Nature Communications · 2018 · 124 citations · Full text

Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate

Yugesh Kharel, Thomas P. Mathews, Amanda M. Gellett et al. · Biochemical Journal · 2011 · 75 citations

Dual Farnesyl and Geranylgeranyl Transferase Inhibitor Thwarts Mutant KRAS-Driven Patient-Derived Pancreatic Tumors

Aslamuzzaman Kazi, Shengyan Xiang, Hua Yang et al. · Clinical Cancer Research · 2019 · 75 citations · Full text

Asymmetric Synthesis of Conformationally Constrained Fingolimod Analogues—Discovery of an Orally Active Sphingosine 1-Phosphate Receptor Type-1 Agonist and Receptor Type-3 Antagonist

Ran Zhu, Ashley H. Snyder, Yugesh Kharel et al. · Journal of Medicinal Chemistry · 2007 · 66 citations · Full text

Discovery, Biological Evaluation, and Structure−Activity Relationship of Amidine Based Sphingosine Kinase Inhibitors

Thomas P. Mathews, Andrew Kennedy, Yugesh Kharel et al. · Journal of Medicinal Chemistry · 2010 · 62 citations

Amidine-based Sphingosine Analogues, Drug Target, Molecular Pharmacology +19