Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense

Xing Wang, Yun Li, Shan Liu, +16

Proceedings of the National Academy of Sciences

Discovery of potent necroptosis inhibitors targeting RIPK1 kinase activity for the treatment of inflammatory disorder and cancer metastasis

Jue Hou, Jie Ju, Zili Zhang, +13

Cell Death and Disease

Necroptosis Mediates TNF-Induced Toxicity of Hippocampal Neurons

Shan Liu, Xing Wang, Yun Li, +6

BioMed Research International

Discovery of a Potent RIPK3 Inhibitor for the Amelioration of Necroptosis-Associated Inflammatory Injury

Kaijiang Xia, Fang Zhu, Chengkui Yang, +13

Frontiers in Cell and Developmental Biology

MicroRNA-381-3p Functions as a Dual Suppressor of Apoptosis and Necroptosis and Promotes Proliferation of Renal Cancer Cells

Cong Zhao, Yifei Zhou, Qiao Ran, +7

Frontiers in Cell and Developmental Biology

Herpes Simplex Virus 1 (HSV-1) and HSV-2 Mediate Species-Specific Modulations of Programmed Necrosis through the Viral Ribonucleotide Reductase Large Subunit R1

Xiaoliang Yu, Yun Li, Qin Chen, +10

Journal of Virology

A novel RIPK1 inhibitor reduces GVHD in mice via a nonimmunosuppressive mechanism that restores intestinal homeostasis

Xiaoliang Yu, Haikuo Ma, Bohan Li, +31

Blood

Systemic GvhdT-regulatory CellImmunologySevere GvhdCell Death +20

Antiviral activity of PHA767491 against human herpes simplex virus in vitro and in vivo

Jue Hou, Zili Zhang, Qiang Huang, +7

BMC Infectious Diseases

Antiviral activity of mitoxantrone dihydrochloride against human herpes simplex virus mediated by suppression of the viral immediate early genes

Qiang Huang, Jue Hou, Peng Yang, +5

BMC Microbiology

Doxorubicin sensitizes cancer cells to Smac mimetic via synergistic activation of the CYLD/RIPK1/FADD/caspase-8-dependent apoptosis

Chengkui Yang, Qiao Ran, Yifei Zhou, +9

APOPTOSIS

Tumor BiologyOncologyCyld/ripk1/fadd/caspase-8-dependent ApoptosisMedicineApoptosis +10