Differential use of importin-α isoforms governs cell tropism and host adaptation of influenza virus

Gülşah Gabriel, Karin Klingel, Anna Otte, +13

Nature Communications

Deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy

Florian Läng, Karin Klingel, Carsten A. Wagner, +18

Proceedings of the National Academy of Sciences

Renal InflammationKinase InhibitorsInsulin SignalingSignaling PathwayDeranged Transcriptional Regulation +19

Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus

Nadine Honke, Namir Shaabani, Giuseppe Cadeddu, +19

Nature Immunology

Viral ReplicationMolecular VirologyViral PersistencePathogenesisImmunology +7

Fatal parvovirus B19–associated myocarditis clinically mimicking ischemic heart disease: An endothelial cell–mediated disease

B. Bültmann, Karin Klingel, Karl Sotlar, +4

Human Pathology

Cardiovascular DiseaseIschemic Heart DiseasePathogenesisImmunologyViral Pathogenesis +8

Cardiomyocyte-specific IκB kinase (IKK)/NF-κB activation induces reversible inflammatory cardiomyopathy and heart failure

Harald J. Maier, Tobias G. Schips, Astrid Wietelmann, +7

Proceedings of the National Academy of Sciences

Pathogenesis of murine enterovirus myocarditis: virus dissemination and immune cell targets

Karin Klingel, Sonja Stephan, Martina Sauter, +4

Journal of Virology

InfectionViral PathogenesisImmunologyPathologyImmune Cell Targets +14

h-sgk serine-threonine protein kinase gene as transcriptional target of transforming growth factor β in human intestine

Siegfried Waldegger, Karin Klingel, Petra Barth, +4

Gastroenterology

Developmental BiologySignal TransductionSignaling PathwayGrowth HormoneTranscriptional Target +6

Cardiac Deletion of the Coxsackievirus-Adenovirus Receptor Abolishes Coxsackievirus B3 Infection and Prevents Myocarditis In Vivo

Yu Shi, Chen Chen, Ulrike Lisewski, +8

Journal of the American College of Cardiology

Viral PathogenesisImmunologyVirologyPrevents MyocarditisCardiac Deletion +5

Ubiquitin-Like Protein ISG15 (Interferon-Stimulated Gene of 15 kDa) in Host Defense Against Heart Failure in a Mouse Model of Virus-Induced Cardiomyopathy

Anna Rahnefeld, Karin Klingel, Anett Schuermann, +14

Circulation

Blocking the IL-1β signalling pathway prevents chronic viral myocarditis and cardiac remodeling

Lisa Kraft, Tugs Erdenesukh, Martina Sauter, +2

Basic Research in Cardiology

InflammationCytokineInflammatory DiseaseViral ImmunityImmune Regulation +9