Georg Vorisek

Skin is an autonomous organ in synthesis, two-step activation and degradation of vitamin D3: CYP27 in epidermis completes the set of essential vitamin D3-hydroxylases

Monika Schuessler, Norbert Astecker, Gerda Herzig et al. · Steroids · 2001 · 104 citations

Life Sciences, Biochemistry, Molecular Biology +11

Selective inhibition of vitamin D hydroxylases in human keratinocytes11Abbreviations: VD: vitamin D3; 25(OH)D3: 25-hydroxyvitamin D3; 3H-25(OH)D3: [26,27n-3H] 25-hydroxyvitamin D3; 1α,25(OH)2D3: 1α,25-dihydroxyvitamin D3; 1α,25(OH)2-3epi-D3: 1α,25-dihydroxyvitamin-3-epi-D3; 1α,24(R),25(OH)3D3: 1α,24(R),25-trihydroxyvitamin D3, 1α,25(OH)2-24oxo-D3: 1α,25-dihydroxy-24oxo-vitamin D3; 1α,23(S),25(OH)3-24oxo-D3: 1α,23(S),25-trihydroxy-24oxo-vitamin D3; calcitroic acid: 1α-hydroxy-23-carboxy-24,25,26,27-tetranorvitamin D3; CYP: cytochrome P450; 1α-hydroxylase: 25-hydroxyvitamin D3-1α-hydroxylase; 24-hydroxylase (CYP24), 1α,25-hydroxyvitamin D3-24-hydroxylase; PHK, primary human keratinocytes; KGM: keratinocyte growth medium; HPLC, high performance liquid chromatography; IC50: half-maximum inhibitor concentration; SD: standard deviation.

Inge Schuster, H. Egger, Daniel D. Bikle et al. · Steroids · 2001 · 75 citations

Medicine, Pharmacology, Enzymology +8

Selective inhibitors of CYP24: mechanistic tools to explore vitamin D metabolism in human keratinocytes

Inge Schuster, H. Egger, Norbert Astecker et al. · Steroids · 2001 · 49 citations

Medicine, Biochemistry, Pharmacology +12

Selective inhibitors of vitamin D metabolism--new concepts and perspectives.

Inge Schuster, H. Egger, Gerda Herzig et al. · PubMed · 2006 · 34 citations

Medicine, Biochemistry, Pharmacology +17

1α,25-Dihydroxy-3-epi-vitamin D3 a physiological metabolite of 1α,25-dihydroxyvitamin D3: Its production and metabolism in primary human keratinocytes

Norbert Astecker, G. Satyanarayana Reddy, Gerda Herzig et al. · Molecular and Cellular Endocrinology · 2000 · 34 citations

Life Sciences, Biochemistry, Dermatology +14