Alexander J. Trostle

Antisense oligonucleotide therapy in a humanized mouse model of <i>MECP2</i> duplication syndrome

Yingyao Shao, Yehezkel Sztainberg, Qi Wang et al. · Science Translational Medicine · 2021 · 59 citations · Full text

Life Sciences, Genetics, Molecular Genetics +9

Losing Dnmt3a dependent methylation in inhibitory neurons impairs neural function by a mechanism impacting Rett syndrome

Laura A. Lavery, Kerstin Ure, Ying‐Wooi Wan et al. · eLife · 2020 · 58 citations · Full text

Medicine, Molecular Biology, Neuroscience +16

Disruption of the ATXN1-CIC complex reveals the role of additional nuclear ATXN1 interactors in spinocerebellar ataxia type 1

Stephanie L. Coffin, Mark A. Durham, Larissa Nitschke et al. · Neuron · 2022 · 28 citations · Full text

Life Sciences, Genetics, Neuroscience +17

Acute MeCP2 loss in adult mice reveals transcriptional and chromatin changes that precede neurological dysfunction and inform pathogenesis

Sameer S. Bajikar, Jian Zhou, Ryan O’Hara et al. · Neuron · 2024 · 26 citations · Full text

Life Sciences, Genetics, Neuroscience +17

Structural variant allelic heterogeneity in MECP2 duplication syndrome provides insight into clinical severity and variability of disease expression

Davut Pehli̇van, Jesse D. Bengtsson, Sameer S. Bajikar et al. · Genome Medicine · 2024 · 16 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17