J. Scott Hayes

Structure-activity relationships of arylimidazopyridine cardiotonics: discovery and inotropic activity of 2-[2-methoxy-4-(methylsulfinyl)phenyl]-1H-imidazo[4,5-c]pyridine

David W. Robertson, E. E. Beedle, Joseph H. Krushinski et al. · Journal of Medicinal Chemistry · 1985 · 73 citations

Combinatorial Chemistry, Heterocyclic, Biochemistry +14

Imidazo[1,2-a]pyrimidines and imidazo[1,2-a]pyrazines: the role of nitrogen position in inotropic activity

Wayne A. Spitzer, Frantz Victor, G. Don Pollock et al. · Journal of Medicinal Chemistry · 1988 · 64 citations

Combinatorial Chemistry, Bioorganic Chemistry, Organic Chemistry +16

Dihydropyridazinone cardiotonics. The discovery and inotropic activity of 1,3-dihydro-3,3-dimethyl-5-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-2H-indol-2-one

David W. Robertson, Joseph H. Krushinski, E. E. Beedle et al. · Journal of Medicinal Chemistry · 1986 · 56 citations

Medicinal Chemistry, Bioorganic Chemistry, Pharmacological Study +15

Molecular structure of the dihydropyridazinone cardiotonic 1,3-dihydro-3,3-dimethyl-5-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-2H-indol-2-one, a potent inhibitor of cyclic AMP phosphodiesterase

David W. Robertson, Noel D. Jones, Joseph H. Krushinski et al. · Journal of Medicinal Chemistry · 1987 · 35 citations

Imidazole-pyridine bioisosterism: comparison of the inotropic activities of pyridine- and imidazole-substituted 6-phenyldihydropyridazinone cardiotonics

David W. Robertson, Joseph H. Krushinski, G. Don Pollock et al. · Journal of Medicinal Chemistry · 1988 · 14 citations