Pavel Y. Savechenkov

Identification of the Clinical Development Candidate <b>MRTX849</b>, a Covalent KRAS^G12C Inhibitor for the Treatment of Cancer

Jay B. Fell, John P. Fischer, Brian R. Baer et al. · Journal of Medicinal Chemistry · 2020 · 594 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Specificity of Intersubunit General Anesthetic-binding Sites in the Transmembrane Domain of the Human α1β3γ2 γ-Aminobutyric Acid Type A (GABAA) Receptor*

David C. Chiara, Selwyn S. Jayakar, Xiaojuan Zhou et al. · Journal of Biological Chemistry · 2013 · 132 citations · Full text

Medicine, Neuroscience, Pharmacology +14

Multiple Propofol-binding Sites in a γ-Aminobutyric Acid Type A Receptor (GABAAR) Identified Using a Photoreactive Propofol Analog

Selwyn S. Jayakar, Xiaojuan Zhou, David C. Chiara et al. · Journal of Biological Chemistry · 2014 · 118 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity

Jay B. Fell, John P. Fischer, Brian R. Baer et al. · ACS Medicinal Chemistry Letters · 2018 · 108 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +15

Anion Binding Modes in <i>meso</i>-Substituted Hexapyrrolic Calix[4]pyrrole Isomers

Kai‐Chi Chang, Tsuyoshi Minami, Petr Koutnı́k et al. · Journal of the American Chemical Society · 2014 · 58 citations

Natural Sciences, Chemistry, Crystal Structure +16